Evidence map›Paper›PMID 30230255›Full record

ArticlePhysiological reports2018

A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm.

Al Mamun, Utako Yokoyama, Junichi Saito, Satoko Ito, Taro Hiromi, Masanari Umemura, Takayuki Fujita, Shota Yasuda, Tomoyuki Minami, Motohiko Goda and 4 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Prostanoids in Cardiac and Vascular Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  3. Novel pharmacological approaches in abdominal aortic aneurysm.Clinical science (London, England : 1979) · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Prostaglandin ECancer science · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Al MamunCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.
Utako YokoyamaCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.ORCID 0000-0003-1803-0155
Junichi SaitoCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.
Satoko ItoCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.
Taro HiromiCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.
Masanari UmemuraCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.
Takayuki FujitaCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.
Shota YasudaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Tomoyuki MinamiCardiovascular Center, Yokohama City University Medical Center, Yokohama, Japan.
Motohiko GodaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Keiji UchidaCardiovascular Center, Yokohama City University Medical Center, Yokohama, Japan.
Shinichi SuzukiDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Munetaka MasudaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Yoshihiro IshikawaCardiovascular Research Institute, Yokohama City University, Yokohama, Japan.
Cardiovascular Institute Hospital · JPYokohama City University · JPYokohama City University Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a progressive disease that has an increasing prevalence with aging, but no effective pharmacological therapy to attenuate AAA progression is currently available. We reported that the prostaglandin E receptor EP4 plays roles in AAA progression. Here, we show the effect of CJ-42794, a selective EP4 antagonist, on AAA using two mouse models (angiotensin II- and CaCl

Indexed as

AnimalsAorta, AbdominalAortic Aneurysm, AbdominalApolipoproteins EBenzenesulfonamidesCells, CulturedHumansImidazolesMaleMiceMice, Inbred C57BLMice, KnockoutPyridinesReceptors, Prostaglandin E, EP4 SubtypeSulfonylurea CompoundsApolipoproteins EBenzenesulfonamidesgrapiprantImidazolesPyridinesReceptors, Prostaglandin E, EP4 SubtypeSulfonylurea CompoundsAbdominal aortic aneurysmelastic fiber, interleukin-6EP4prostaglandin E

Identifiers

PMID30230255
PMCPMC6144453
OpenAlexW2891231148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.