ArticleMolecular ecology2018
Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats.
Article in Molecular ecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- On the Origin and Evolution of Sweet Taste Mediated by Tas1r2-Tas1r3 in Vertebrates.Integrative zoology · 2026Article
- Evolution of Phospholipase A2 in Bees and Flies.Ecology and evolution · 2025Article
- Functional Decline of a Bitter Receptor Gene in New World Vultures.Molecular biology and evolution · 2025Article
- Taste receptors and their ecological niches: cats, dogs, and other vertebrates.Chemical senses · 2025Review
- Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians.PLoS genetics · 2025Article
- The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies.International journal of molecular sciences · 2024Review
- Relationships between Bitter Taste Receptor Gene Evolution, Diet, and Gene Repertoire in Primates.Genome biology and evolution · 2024Article
- The evolution of bitter taste receptor gene in primates: Gene duplication and selection.Ecology and evolution · 2023Article
- Evolution of bitter receptor genes and ontogenetic dietary shift in a frog.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genome assembly of an Australian native grass species reveals a recent whole-genome duplication and biased gene retention of genes involved in stress response.GigaScience · 2022Article
- Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals.Molecular biology and evolution · 2022Article
- Local Adaptation of Bitter Taste and Ecological Speciation in a Wild Mammal.Molecular biology and evolution · 2021Article
- Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16?Proceedings. Biological sciences · 2021Article
- Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ionsProceedings. Biological sciences · 2021Article
- Loss of sweet taste despite the conservation of sweet receptor genes in insectivorous bats.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structure-Function Analyses of Human Bitter Taste Receptors-Where Do We Stand?Molecules (Basel, Switzerland) · 2020Review
- Functional divergence of bitter taste receptors in a nectar-feeding bird.Biology letters · 2019Article
- Origin and evolution of the major histocompatibility complex class I region in eutherian mammals.Ecology and evolution · 2019Article
- Metal Ions Activate the Human Taste Receptor TAS2R7.Chemical senses · 2019Article
- The evolution of S100A7: an unusual gene expansion in Myotis bats.BMC evolutionary biology · 2019Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
By generating raw genetic material and diverse biological functions, gene duplication represents a major evolutionary mechanism that is of fundamental importance in ecological adaptation. The lineage-specific duplication events of bitter taste receptor genes (Tas2rs) have been identified in a number of vertebrates, but functional evolution of new Tas2r copies after duplication remains largely unknown. Here, we present the largest data set of bat Tas2rs to date, identified from existing genome sequences of 15 bat species and newly sequenced from 17 bat species, and demonstrate lineage-specific duplications of Tas2r16, Tas2r18 and Tas2r41 that only occurred in Myotis bats. Myotis bats are highly speciose and represent the only mammalian genus that is naturally distributed on every continent except Antarctica. The occupation of such diverse habitats might have driven the Tas2r gene expansion. New copies of Tas2rs in Myotis bats have shown molecular adaptation and functional divergence. For example, three copies of Tas2r16 in Myotis davidii showed differential sensitivities to arbutin and salicin that may occur in their insect prey, as suggested by cell-based functional assays. We hypothesize that functional differences among Tas2r copies in Myotis bats would increase their survival rate through preventing the ingestion of an elevated number of bitter-tasting dietary toxins from their insect prey, which may have facilitated their adaptation to diverse habitats. Our study demonstrates functional changes of new Tas2r copies after lineage-specific duplications in Myotis bats and highlights the potential role of taste perception in exploiting new environments.
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