Evidence map›Paper›PMID 30230006›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2019

High muscle co-contraction does not result in high joint forces during gait in anterior cruciate ligament deficient knees.

Ashutosh Khandha, Kurt Manal, Jacob Capin, Elizabeth Wellsandt, Adam Marmon, Lynn Snyder-Mackler, Thomas S Buchanan

Abstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Males and females have different muscle activity patterns during gait after ACL injury and reconstruction.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2022
    Article
  7. Knee joint biomechanics during gait improve from 3 to 6 months after anterior cruciate ligament reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Operative and nonoperative management of anterior cruciate ligament injury: Differences in gait biomechanics at 5 years.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Article
  12. Slower Walking Speed Is Related to Early Femoral Trochlear Cartilage Degradation After ACL Reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ashutosh KhandhaBiomechanics and Movement Science, University of Delaware, 540 South College Avenue, Newark 19713, Delaware.ORCID 0000-0001-6003-3881
Kurt ManalDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware.
Jacob CapinBiomechanics and Movement Science, University of Delaware, 540 South College Avenue, Newark 19713, Delaware.ORCID 0000-0001-9361-3700
Elizabeth WellsandtDivision of Physical Therapy, University of Nebraska Medical Center, Omaha, Nebraska.
Adam MarmonBiomechanics and Movement Science, University of Delaware, 540 South College Avenue, Newark 19713, Delaware.
Lynn Snyder-MacklerBiomechanics and Movement Science, University of Delaware, 540 South College Avenue, Newark 19713, Delaware.
Thomas S BuchananBiomechanics and Movement Science, University of Delaware, 540 South College Avenue, Newark 19713, Delaware.
South College · USKessler Institute for Rehabilitation · USNebraska Medical Center · USUniversity of Delaware · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
Pilot Project ProgramP30GM103333 · NIGMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 2012 to 2016
$5.7M
Dynamic Stability in the ACL Injured KneeR37HD037985 · NICHD · UNIVERSITY OF DELAWARE · PI GRAVARE SILBERNAGEL, KARIN M E · 2012 to 2021
$4.2M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
CAN NEUROMUSCULAR TRAINING ALTER MOVEMENT PATTERNS?R01AR048212 · NIAMS · UNIVERSITY OF DELAWARE · PI SNYDER-MACKLER, LYNN · 2005 to 2015
$3.6M
ACL Injured Knee: MRI and Biomechanical ModelingR01AR046386 · NIAMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 1999 to 2011
$2.8M
ACL Reconstructed Knee: qMRI and Biomechanical ModelingR01HD087459 · NICHD · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 2016 to 2020
$1.8M
Walking Mechanics, Early Osteoarthritis Development, and Neuromuscular Training after Traumatic Knee InjuryF30HD096830 · NICHD · UNIVERSITY OF DELAWARE · PI CAPIN, JACOB J · 2018 to 2019
$53k
NIAMS NIH HHS R01 AR046386NIAMS NIH HHS R01 AR048212NICHD NIH HHS F30 HD096830NICHD NIH HHS R01 HD087459NICHD NIH HHS R37 HD037985NICHD NIH HHS T32 HD007490NIGMS NIH HHS P30 GM103333NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

The mechanism of knee osteoarthritis development after anterior cruciate ligament injuries is poorly understood. The objective of this study was to evaluate knee gait variables, muscle co-contraction indices and knee joint loading in young subjects with anterior cruciate ligament deficiency (ACLD, n = 36), versus control subjects (n = 12). A validated, electromyography-informed model was used to estimate joint loading. For the involved limb of ACLD subjects versus control, muscle co-contraction indices were higher for the medial (p = 0.018, effect size = 0.93) and lateral (p = 0.028, effect size = 0.83) agonist-antagonist muscle pairs. Despite higher muscle co-contraction, medial compartment contact force was lower for the involved limb, compared to both the uninvolved limb (mean difference = 0.39 body weight, p = 0.009, effect size = 0.70) as well as the control limb (mean difference = 0.57 body weight, p = 0.007, effect size = 1.14). Similar observations were made for total contact force. For involved versus uninvolved limb, the ACLD group demonstrated lower vertical ground reaction force (mean difference = 0.08 body weight, p = 0.010, effect size = 0.70) and knee flexion moment (mean difference = 1.32% body weight * height, p = 0.003, effect size = 0.76), during weight acceptance. These results indicate that high muscle co-contraction does not always result in high knee joint loading, which is thought to be associated with knee osteoarthritis. Long-term follow-up is required to evaluate how gait alterations progress in non-osteoarthritic versus osteoarthritic subjects. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

Indexed as

GaitAdolescentAdultAnterior Cruciate Ligament InjuriesCase-Control StudiesFemaleHumansKnee JointMaleMuscle ContractionQuadriceps MuscleWeight-BearingYoung AdultACLjoint forceskneemuscle co-contractionmusculoskeletal modeling

Identifiers

PMID30230006
PMCPMC6393175
OpenAlexW2891062739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.