Evidence map›Paper›PMID 30229990›Full record

ArticleClinical endocrinology2019

Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic-hyperinsulinemic clamps.

Weiping Li, Qingfeng Chen, Yikai Xie, Jinbo Hu, Shumin Yang, Miaozhi Lin

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In one paragraph

Article in Clinical endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weiping LiDepartment of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.ORCID 0000-0001-6603-7939
Qingfeng ChenDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0003-2014-2156
Yikai XieDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jinbo HuDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shumin YangDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Miaozhi LinDepartment of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe euglycemic-hyperinsulinemic clamp is the gold standard to evaluate insulin resistance (IR), but there are only a few studies on the prevalence of IR in Chinese Han women with polycystic ovary syndrome (PCOS). This study investigated: (a) the prevalence of IR in Chinese Han women with PCOS by clamp, (b) the degree of reduction in insulin sensitivity (IS) and the contribution of body mass index (BMI).

designRetrospective cross-sectional analysis. PATIENTS: Chinese Han women with PCOS (n = 448) visiting the Department of Endocrinology or the Department of Obstetrics and Gynaecology of the First Affiliated Hospital of Chongqing Medical University. Chinese Han women without PCOS (controls) from the same area (n = 40). MEASUREMENTS: Clamp-measured IS, age, BMI, and total testosterone.

resultsThe prevalence of IR and reduction in IS were 56.3% and 30.3%, respectively, in Chinese Han women with PCOS (both P < 0.001). The inherent reduction in IS was 18.8% in lean women with PCOS and BMI independently reduced IS by 37.9% in obese women with PCOS. The prevalence of IR estimated by homeostatic model assessment (HOMA) was lower than that determined by clamp. The multivariable analysis showed that IR by clamp (R

conclusions56.3% of Chinese Han women with PCOS had IR and their reduction in IS was 30.3%. Obesity exacerbated the reduction in IS. When being evaluated by HOMA, the prevalence and the risk factors of IR in Chinese women with PCOS were underestimated.

Indexed as

Insulin ResistanceAdultBody Mass IndexCase-Control StudiesChinaCross-Sectional StudiesFemaleGlucose Clamp TechniqueHumansObesityPolycystic Ovary SyndromePrevalenceRetrospective StudiesWaist-Hip RatioYoung Adult

Identifiers

PMID30229990
PMCPMC7380049

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.