ReviewParasite immunology2019
Soil-transmitted helminth parasites and allergy: Observations from Ecuador.
Review in Parasite immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- A historical and systematic overview ofParasitology · 2021Pooled it
- Soil-Transmitted Helminth Infection in Malaysia: Protocol for a Scoping Review.JMIR research protocols · 2022Article
- Zoonotic Ancylostoma ceylanicum Hookworm Infections, Ecuador.Emerging infectious diseases · 2022Article
- Concurrent allergy and helminthiasis in underprivileged urban South African adults previously residing in rural areas.Parasite immunology · 2022Article
- Asthma, rhinitis and eczema symptoms in Quito, Ecuador: a comparative cross-sectional study 16 years after ISAAC.BMJ open respiratory research · 2021Article
- Trends in hospital admissions and mortality rates for asthma in Ecuador: a joinpoint regression analysis of data from 2000 to 2018.BMJ open respiratory research · 2021Article
- Food allergy, airborne allergies, and allergic sensitisation among adolescents living in two disparate socioeconomic regions in Ecuador: A cross-sectional study.The World Allergy Organization journal · 2020Article
- Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma.Allergy, asthma & immunology research · 2020Review
- Helminth Induced Immunoregulation and Novel Therapeutic Avenue of Allergy.Journal of asthma and allergy · 2020Review
- Exposure to Ascaris lumbricoides infection and risk of childhood asthma in north of Iran.Infection · 2019Article
- Trickle infection and immunity to Trichuris muris.PLoS pathogens · 2019Article
- Soil-transmitted helminth parasites and allergy: Observations from Ecuador.Parasite immunology · 2019Review
- Hemozoin From the Liver Fluke,Frontiers in veterinary science · 2019Article
- Prevalence and associated factors for asthma in adults in Quito: a cross-sectional study.Colombia medica (Cali, Colombia)Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
There is considerable interest as to potential protective effects of soil-transmitted helminths (STH) against allergy and allergic diseases. Here, we discuss findings of studies done of the effects of STH parasites on atopy and allergic diseases in Ecuador. While cross-sectional studies have consistently shown a reduced prevalence of allergen skin prick test (SPT) reactivity among infected schoolchildren, the removal of these infections by repeated deworming did not affect SPT prevalence over the short-term (ie, 12 months) but may have increased SPT prevalence over the long-term (ie, 15-17 years). In the case of allergic symptoms, cross-sectional studies have generally not shown associations with STH and intervention studies showed no impact on prevalence. However, a birth cohort suggested that early STH infections might reduce wheeze by 5 years. Allergic sensitization to Ascaris, however, explained a significant proportion of wheezing among rural schoolchildren. Studies of the effects of STH on immune and inflammatory responses indicated a potential role of STH in contributing to more robust regulation. The effects of STH on allergy are likely to be determined by history of exposure over the life-course and by interactions with a wide variety of other infectious and non-infectious factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.