Evidence map›Paper›PMID 30229863›Full record

ArticleClinical and experimental immunology2018

Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence.

M-N Theodoraki, T K Hoffmann, E K Jackson, T L Whiteside

Abstract read
In one paragraph

Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
  2. Article
  3. Immune biomarkers for head and neck cancer.Cancer immunology, immunotherapy : CII · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Tumor-derived Exosomes and Antitumor Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Review
  9. Tumor-associated genetic amplifications impact extracellular vesicle miRNA cargo and their recruitment of nerves in head and neck cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M-N TheodorakiDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
T K HoffmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, Ulm, Germany.
E K JacksonDepartments of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
T L WhitesideDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
The Guanosine-Adenosine MechanismR01HL109002 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2012 to 2023
$5.1M
Adenosine in Renal Sympathetic NeurotransmissionR01DK091190 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2011 to 2020
$3.4M
Restoring anti-tumor immunity in the microenvironment of head and neck cancerR01CA168628 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA168628NHLBI NIH HHS R01 HL109002NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK091190
6 · The paper itself

Abstract

Exosomes in plasma of head and neck squamous cell carcinoma (HNSCC) patients comprise subsets of vesicles derived from various cells. Recently, we separated CD3

Indexed as

5'-NucleotidaseAdenosineAdenosine DeaminaseApyraseCD3 ComplexDipeptidyl Peptidase 4ExosomesFemaleGPI-Linked ProteinsHead and Neck NeoplasmsHumansMaleMass SpectrometryMiddle AgedPhotochemotherapySquamous Cell Carcinoma of Head and Neck5'-NucleotidaseAdenosineAdenosine DeaminaseApyraseCD3 ComplexDipeptidyl Peptidase 4DPP4 protein, humanENTPD1 protein, humanGPI-Linked ProteinsNT5E protein, humanadenosineadenosine deaminaseHNSCCimmunmodulationT cell-derived exosomestumour-derived exosomes (TEX)

Identifiers

PMID30229863
PMCPMC6156813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.