Evidence map›Paper›PMID 30229768›Full record

ArticleBiomaterials science2018

Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides.

Hamilton Kakwere, Elizabeth S Ingham, Riley Allen, Lisa M Mahakian, Sarah M Tam, Hua Zhang, Matthew T Silvestrini, Jamal S Lewis, Katherine W Ferrara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hamilton KakwereDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA and Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305, USA. kwferrara@ucdavis.edu kwferrar@stanford.edu.ORCID http://orcid.org/0000-0002-1934-4992
Elizabeth S InghamDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA.
Riley AllenDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA.
Lisa M MahakianDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA.
Sarah M TamDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA.
Hua ZhangDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA and Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305, USA. kwferrara@ucdavis.edu kwferrar@stanford.edu.ORCID http://orcid.org/0000-0001-9696-5322
Matthew T SilvestriniDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA.
Jamal S LewisDepartment of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA.ORCID http://orcid.org/0000-0002-9811-8538
Katherine W FerraraMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305, USA. kwferrara@ucdavis.edu kwferrar@stanford.edu.ORCID http://orcid.org/0000-0002-4976-9107

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Specific and high-resolution ultrasound cancer imagingR01CA112356 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI FERRARA, KATHERINE W, FOIRET, JOSQUIN · 2005 to 2022
$6.1M
Ultrasound imaging and enhanced therapeutic responseR01CA134659 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W · 2009 to 2017
$4.4M
Large aperture and wideband modular ultrasound arrays for the diagnosis of liver cancerR01CA211602 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W, TRAHEY, GREGG E. · 2017 to 2021
$3.3M
Image-guided ultrasound therapy and drug delivery in pancreatic cancerR01CA210553 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W · 2016 to 2020
$3.2M
Optimized ultrasound-enhanced immunotherapyR01CA199658 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W · 2015 to 2019
$2.5M
NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA112356NCI NIH HHS R01 CA134659NCI NIH HHS R01 CA199658NCI NIH HHS R01 CA210553NCI NIH HHS R01 CA211602
6 · The paper itself

Abstract

Unimicellar hyperstar macromolecular chimeras displaying multiple melanoma peptide antigens were prepared primarily via a combination of click chemistry and esterification reactions starting from a biodegradable hyperbranched polymer template. Solubilization of the hyperstars in aqueous solution afforded a multi-antigen unimicellar cancer nanovaccine of about 20 nm. The nanovaccine showed good biocompatibility and uptake by dendritic cells in vitro. An in vivo evaluation of the nanovaccine therapeutic efficacy against melanoma in mice implanted with B16OVA tumors revealed significantly greater T-cell recruitment and improved survival rates for mice treated with nanovaccine and adjuvant compared to non-treated mice.

Indexed as

MicellesAdjuvants, ImmunologicAmino Acid SequenceAnimalsAntigens, NeoplasmCancer VaccinesEpitopesMelanomaMiceNanostructuresPeptidesAdjuvants, ImmunologicAntigens, NeoplasmCancer VaccinesEpitopesMicellesPeptides

Identifiers

PMID30229768
PMCPMC6261306

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.