ArticlePsychological medicine2019
Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults.
Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Pooled it
- A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression.Journal of psychiatric research · 2021Pooled it
- Adolescents' ventral striatal reward neural activity moderates the association between lifetime trauma exposure and lower depression after 6 months.European journal of psychotraumatology · 2026Article
- Neural response to reward as a potential pathway from inflammation to anhedonia in adolescents at risk for depression.Brain, behavior, & immunity - health · 2026Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- Trauma and anxiety interactions relate to reward processing in adolescents.Journal of affective disorders · 2025Article
- Article
- Childhood adversities and suicidal ideation among young adults with serious mental illnesses: The mediating roles of perceived stress, dispositional hope, and mental health hope.Journal of affective disorders · 2025Article
- Neurobehavioral Reward and Sleep-Circadian Profiles Predict Present and Next-Year Mania/Hypomania Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Splitting the reward: Differences in inflammatory marker associations with neural connectivity between reward anticipation and reward outcome in adolescents at high risk for depression.Journal of affective disorders · 2023Article
- Neural activations to loss anticipation mediates the association between difficulties in emotion regulation and screen media activities among early adolescent youth: A moderating role for depression.Developmental cognitive neuroscience · 2022Article
- Medial Prefrontal Cortex Activity to Reward Outcome Moderates the Association Between Victimization Due to Sexual Orientation and Depression in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Enduring effect of abuse: Childhood maltreatment links to altered theory of mind network among adults.Human brain mapping · 2022Article
- Trauma Affects Prospective Relationships Between Reward-Related Ventral Striatal and Amygdala Activation and 1-Year Future Hypo/Mania Trajectories.Biological psychiatry · 2021Article
- The contributions of the endocannabinoid system and stress on the neural processing of reward stimuli.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Task MRI-Based Functional Brain Network of Major Depression.Advances in experimental medicine and biology · 2021Article
- Anhedonia Reduction and the Association Between Left Ventral Striatal Reward Response and 6-Month Improvement in Life Satisfaction Among Young Adults.JAMA psychiatry · 2019Article
- Investigation of functional brain network reconfiguration during vocal emotional processing using graph-theoretical analysis.Social cognitive and affective neuroscience · 2019Article
- Dissociation between Cerebellar and Cerebral Neural Activities in Humans with Long-Term Bilateral Sensorineural Hearing Loss.Neural plasticity · 2019Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTrauma exposure is associated with development of depression and anxiety; yet, some individuals are resilient to these trauma-associated effects. Differentiating mechanisms underlying development of negative affect and resilience following trauma is critical for developing effective interventions. One pathway through which trauma could exert its effects on negative affect is reward-learning networks. In this study, we examined relationships among lifetime trauma, reward-learning network function, and emotional states in young adults.
methodsOne hundred eleven young adults self-reported trauma and emotional states and underwent functional magnetic resonance imaging during a monetary reward task. Trauma-associated neural activation and functional connectivity were analyzed during reward prediction error (RPE). Relationships between trauma-associated neural functioning and affective and anxiety symptoms were examined.
resultsNumber of traumatic events was associated with greater ventral anterior cingulate cortex (vACC) activation, and lower vACC connectivity with the right insula, frontopolar, inferior parietal, and temporoparietal regions, during RPE. Lower trauma-associated vACC connectivity with frontoparietal regions implicated in regulatory and decision-making processes was associated with heightened affective and anxiety symptoms; lower vACC connectivity with insular regions implicated in interoception was associated with lower affective and anxiety symptoms.
conclusionsIn a young adult sample, two pathways linked the impact of trauma on reward-learning networks with higher v. lower negative affective and anxiety symptoms. The disconnection between vACC and regions implicated in decision-making and self-referential processes may reflect aberrant regulatory but appropriate self-focused mechanisms, respectively, conferring risk for v. resilience against negative affective and anxiety symptoms.
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