Evidence map›Paper›PMID 30229446›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2019

Incidence, risk factors and clinical impact of postoperative delirium following open reduction and internal fixation (ORIF) for hip fractures: an analysis of 7859 patients from the ACS-NSQIP hip fracture procedure targeted database.

Azeem Tariq Malik, Carmen E Quatman, Laura S Phieffer, Thuan V Ly, Safdar N Khan

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04335461 early_phase1withdrawnnot on this mapstarted 2021, after this paper: background citation

Postoperative Pain Control in Extracapsular Hip Fracture Patients: Fascia Iliaca Compartment Block Versus Fracture Block

TypeinterventionalSponsorMontefiore Medical CenterRan2021 to 2023Enrolled0ConditionsHip Fractures, Analgesia, Opioid Use, Pain, PostoperativeArmsCephalomedullary nailing of extracapsular hip fracture, cephalomedullary nail, Regional Anesthetics
NCT04955249 phase4terminatednot on this mapstarted 2021, after this paper: background citation

Impact of Dexmedetomidine Supplemented Analgesia on Delirium and Long-term Outcomes in Elderly After Hip Fracture Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2021 to 2023Enrolled67ConditionsElderly, Hip Fracture Surgery, Patient-controlled Analgesia, DexmedetomidineArmsDexmedetomidine, Placebo
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 57 citations in OpenAlex.

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  8. Author Response: Nocturnal Infusion of Low-dose Dexmedetomidine and Propofol for Delirium Prevention.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
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  14. Delirium in a surgical context from a nursing perspective: A hybrid concept analysis.International journal of nursing studies advances · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Azeem Tariq MalikThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Carmen E QuatmanThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Laura S PhiefferThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Thuan V LyThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Safdar N KhanThe Ohio State University Wexner Medical Center, Columbus, OH, USA. Safdar.Khan@osumc.edu.
The Ohio State University Wexner Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDelirium is one of the most common acute psychiatric disturbances taking place in patients, particularly elderly, following hip fractures. Using a validated national surgical database, we sought to define the incidence, risk factors and clinical impact associated with the occurrence of delirium following open reduction and internal fixation (ORIF) for hip fracture.

methodsThe 2016 American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) Hip Fracture Targeted Procedure file-was retrieved and merged with the ACS-NSQIP 2016 file. A total of 7859 patients were finally included in the study.

resultsA total of 2177 (27.7%) patients experienced an episode of delirium following the procedure. Adjusted analysis showed an increasing age ≥ 65 years (p < 0.001), partially dependent functional health status prior to surgery (p = 0.001), bleeding disorder (p = 0.012), preoperative dementia (p < 0.001), preoperative delirium (p < 0.001), being bed-ridden postoperatively (p < 0.001), no weight bearing as tolerated on first postoperative day (p < 0.001), an ASA grade > II (p < 0.001), non-emergency case (p = 0.010) and a prolonged length of stay > 3 days (p < 0.001). In addition, Black or African-American ethnicity had a lower odds of developing postoperative delirium (p = 0.020) as compared to Whites. Moreover, postoperative delirium was significantly associated with non-home discharge disposition (p < 0.001), higher odds of 30-day readmissions (p < 0.001) and 30-day mortality (p < 0.001).

conclusionThis study identifies several risk factors associated with the occurrence of postoperative delirium in patients undergoing ORIF for hip fracture. Surgeons can utilize these data to risk stratify and consequently tailor an appropriate preoperative and postoperative care protocol to prevent the occurrence of delirium.

Indexed as

AgedAged, 80 and overAge FactorsBedridden PersonsBlood Coagulation DisordersDatabases, FactualDementiaEmergence DeliriumFemaleFracture Fixation, InternalHealth StatusHip FracturesHumansIncidenceLength of StayMaleDeliriumHip fractureNSQIPOpen reduction internal fixationORIF delirium

Identifiers

PMID30229446
OpenAlexW2892074373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.