Evidence map›Paper›PMID 30229395›Full record

ReviewCurrent neurology and neuroscience reports2018

Acute Treatment of Stroke (Except Thrombectomy).

Paula Muñoz Venturelli, Jason P Appleton, Craig S Anderson, Philip M Bath

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Paula Muñoz VenturelliClinical Research Center, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Jason P AppletonStroke Trials Unit, Division of Clinical Neurosciences, University of Nottingham, Nottingham, UK.
Craig S AndersonClinical Research Center, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, Chile. canderson@georgeinstitute.org.au.
Philip M BathStroke Trials Unit, Division of Clinical Neurosciences, University of Nottingham, Nottingham, UK.
Clínica Alemana · CLNottingham University Hospitals NHS Trust · GBUniversidad del Desarrollo · CLUniversity of Nottingham · GB

Funding

Medical Research Council G0501797
6 · The paper itself

Abstract

purpose of reviewThe management of patients with acute stroke has been revolutionized in recent years with the advent of new effective treatments. In this rapidly evolving field, we provide an update on the management of acute stroke excluding thrombectomy, looking to recent, ongoing, and future trials. RECENT

findingsLarge definitive trials have provided insight into acute stroke care including broadening the therapeutic window for thrombolysis, alternatives to standard dose alteplase, the use of dual antiplatelet therapy early after minor ischemic stroke, and treating elevated blood pressure in intracerebral hemorrhage. Further ongoing and future trials are eagerly awaited in this ever-expanding area. Although definitive trials have led to improvements in acute stroke care, there remains a need for further research to improve our understanding of pathophysiological mechanisms underlying different stroke types with the potential for treatments to be tailored to the individual.

Indexed as

ThrombectomyBrain IschemiaCerebral HemorrhageClinical Trials as TopicCritical CareFibrinolytic AgentsHumansPlatelet Aggregation InhibitorsStrokeThrombolytic TherapyTissue Plasminogen ActivatorFibrinolytic AgentsPlatelet Aggregation InhibitorsTissue Plasminogen ActivatorAcute ischemic strokeAntiplateletsBlood pressureIntracerebral hemorrhageStroke unitThrombolysis

Identifiers

PMID30229395
OpenAlexW2889798140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.