Evidence map›Paper›PMID 30229392›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2019

Effect of Paclitaxel-based Hyperthermic Intraperitoneal Chemotherapy (HIPEC) on colonic anastomosis in a rat model.

V López-López, P B Lynn, J Gil, M García-Salom, E Gil, A González, I P Muñoz, P A Cascales-Campos

Abstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

V López-LópezVirgen de la Arrixaca Clinic and University Hospital, General Surgery, IMIB, El Palmar, Murcia, Spain. victorrelopez@gmail.com.ORCID http://orcid.org/0000-0003-1718-3352
P B LynnSurgery Department, New York University School of Medicine, New York, NY, USA.
J GilVirgen de la Arrixaca Clinic and University Hospital, General Surgery, IMIB, El Palmar, Murcia, Spain.
M García-SalomVirgen de la Arrixaca Clinic and University Hospital, General Surgery, IMIB, El Palmar, Murcia, Spain.
E GilVirgen de la Arrixaca Clinic and University Hospital, General Surgery, IMIB, El Palmar, Murcia, Spain.
A GonzálezGerencia del Area de Salud III (Lorca), Murcia, Spain.
I P MuñozHospital Virgen del Castillo (Yecla), Murcia, Spain.
P A Cascales-CamposVirgen de la Arrixaca Clinic and University Hospital, General Surgery, IMIB, El Palmar, Murcia, Spain.
Hospital Virgen del Puerto · ESInstituto Murciano de Investigación Biosanitaria · ESNew York University · USServicio Murciano de Salud · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPaclitaxel has been used frequently for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for ovarian carcinomatosis. Cytoreductive surgery and HIPEC are associated with high rates of morbidity being anastomotic dehiscence one of the most frequent. The objective of this study is to quantify the effect of Paclitaxel-based HIPEC on colonic anastomosis in an experimental rat model.

methodsAfter left colon resection and anastomosis, animals were randomized into four groups: Controls (C); Hyperthermia (H); Normothermic Intraperitoneal Paclitaxel (CP) and Paclitaxel-based HIPEC (HP). On postoperative day four, animals' peritoneal cavities were examined macroscopically, colon anastomosis burst pressures measured and specimens analyzed histologically.

resultsThirty-nine animals were randomized and 36 were included in the analysis. H group presented the highest burst pressure 105.11 ± 22.9 mmHg, which was 27% higher than C (77.89 ± 27.6 mmHg). On the other hand, HP presented the lowest burst pressure 64 ± 26 mmHg, 16% lower than C group and 39% lower than H, being this latter difference statistically significant (p = 0.004). There were no significant differences regarding weight loss, adhesion scores, perianastomotic abscesses and histological findings (inflammation, fibroblasts, neoangiogenesis, and collagen among groups).

conclusionStrength of colonic anastomosis was improved by isolated hyperthermia and negatively affected by Paclitaxel-based HIPEC.

Indexed as

Hyperthermia, InducedAnastomosis, SurgicalAnastomotic LeakAnimalsAntineoplastic Agents, PhytogenicColonMaleModels, AnimalPaclitaxelRats, Sprague-DawleyAntineoplastic Agents, PhytogenicPaclitaxelColonic anastomosesHealingHyperthermic Intraperitoneal ChemotherapyPaclitaxel

Identifiers

PMID30229392
OpenAlexW2890157840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.