Evidence map›Paper›PMID 30229325›Full record

ArticleApplied microbiology and biotechnology2018

Enhanced synthesis of poly gamma glutamic acid by increasing the intracellular reactive oxygen species in the Bacillus licheniformis Δ1-pyrroline-5-carboxylate dehydrogenase gene ycgN-deficient strain.

Bichan Li, Dongbo Cai, Shiying Hu, Anting Zhu, Zhili He, Shouwen Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. AdvancingMicroorganisms · 2024
    Review
  4. Celastrol Combats Methicillin-Resistant Staphylococcus aureus by Targeting ΔAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bichan LiState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.
Dongbo CaiEnvironmental Microbial Technology Center of Hubei Province, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, College of Life Sciences, Hubei University, No. 368 Youyi Avenue, Wuchang District, Wuhan, 430062, Hubei, People's Republic of China.
Shiying HuEnvironmental Microbial Technology Center of Hubei Province, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, College of Life Sciences, Hubei University, No. 368 Youyi Avenue, Wuchang District, Wuhan, 430062, Hubei, People's Republic of China.
Anting ZhuEnvironmental Microbial Technology Center of Hubei Province, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, College of Life Sciences, Hubei University, No. 368 Youyi Avenue, Wuchang District, Wuhan, 430062, Hubei, People's Republic of China.
Zhili HeState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.
Shouwen ChenState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China. mel212@126.com.ORCID http://orcid.org/0000-0003-3503-4561
Hubei University · CNHuazhong Agricultural University · CNSun Yat-sen University · CN

Funding

the National Program on Key Basic Research Project 2015CB150505the Science and Technology Program of Wuhan 20160201010086the Technical Innovation Special Fund of Hubei Province 2018ACA149
6 · The paper itself

Abstract

Poly gamma glutamic acid (γ-PGA) is an anionic polyamide with numerous applications. Previous studies revealed that L-proline metabolism is implicated in a wide range of cellular processes by increasing intercellular reactive oxygen species (ROS) generation. However, the relationship between L-proline metabolism and γ-PGA synthesis has not yet been analyzed. In this study, our results confirmed that deletion of Δ1-pyrroline-5-carboxylate dehydrogenase gene ycgN in Bacillus licheniformis WX-02 increased γ-PGA yield to 13.91 g L

Indexed as

1-Pyrroline-5-Carboxylate DehydrogenaseBacillus licheniformisBacterial ProteinsCytoplasmGene DeletionPolyglutamic AcidReactive Oxygen Species1-Pyrroline-5-Carboxylate DehydrogenaseBacterial Proteinspoly(gamma-glutamic acid)Polyglutamic AcidReactive Oxygen SpeciesBacillus licheniformisPoly gamma glutamic acidProline metabolismReactive oxygen speciesYcgN

Identifiers

PMID30229325
OpenAlexW2953141265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.