ArticleEuropean radiology2019
Quantitative assessment of mesorectal fat: new prognostic biomarker in patients with mid-to-lower rectal cancer.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adiposity and cancer survival: a systematic review and meta-analysis.Cancer causes & control : CCC · 2022Pooled it
- Article
- Beyond the tumor region: Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer.World journal of gastroenterology · 2025Article
- Predicting 3-year all-cause mortality in rectal cancer patients based on body composition and machine learning.Frontiers in nutrition · 2025Article
- Correlation study of functional magnetic resonance index and clinicopathological features of rectal cancer.Abdominal radiology (New York) · 2024Article
- A narrative review of prognostic indices in the evaluation of gastrointestinal cancers.Journal of gastrointestinal oncology · 2023Review
- The impact of mesorectal fat area on recurrence following total mesorectal excision for lower rectal cancer.Langenbeck's archives of surgery · 2023Article
- Quantitative assessment of the microstructure of the mesorectum with different prognostic statuses by intravoxel incoherent motion diffusion-weighed magnetic resonance imaging.BMC gastroenterology · 2022Article
- Identification of an endoplasmic reticulum stress-related signature associated with clinical prognosis and immune therapy in glioma.BMC neurology · 2022Article
- Lymph Nodes Evaluation in Rectal Cancer: Where Do We Stand and Future Perspective.Journal of clinical medicine · 2022Review
- Role of Perirectal Fat in the Carcinogenesis and Development of Early-Onset Rectal Cancer.Journal of oncology · 2022Article
- MRI-based clinical-radiomics model predicts tumor response before treatment in locally advanced rectal cancer.Scientific reports · 2021Article
- High body mass index is associated with an increased overall survival in rectal cancer.Journal of gastrointestinal oncology · 2020Article
- Low expression of miR-125a-5p is associated with poor prognosis in patients with gastric cancer.Oncology letters · 2019Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the impact of mesorectal fat area (MFA) on oncologic outcomes in patients with mid-to-lower rectal cancer who received curative-intent surgery.
methodsPatients with mid-to-lower rectal cancer who underwent preoperative abdominopelvic computed tomography (CT) and curative-intent surgery in 2011 were divided into two groups by tumour recurrence (group A) or no recurrence (group B) during a 5-year follow-up. Visceral fat area (VFA) and MFA were measured on preoperative CT and cutoff values were calculated using the Youden index. Univariate and multivariate regression analyses including BMI, VFA, and MFA were performed to investigate meaningful prognostic biomarkers. The Kaplan-Meier method with log-rank testing was used to validate prognostic biomarkers.
resultsGroup A contained 42 patients and group B had 155 patients. Cutoff values were 25 kg/m
conclusionsMFA was an independent biomarker for predicting DFS in patients who underwent curative-intent surgery for mid-to-lower rectal cancer. KEY POINTS: • Mesorectal fat area is associated with the prognosis of rectal cancer patients. • Mesorectal fat area can be calculated easily in pre-operative CT scan. • Predicting prognosis of the cancer patient before operation is important.
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