Evidence map›Paper›PMID 30229154›Full record

ArticlePediatric quality & safety

Variation in Gentamicin Dosing and Monitoring in Pediatric Units across New South Wales.

Vishal Saddi, John Preddy, Sarah Dalton, John Connors, Sarah Patterson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric quality & safety. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vishal SaddiDepartment of Paediatrics, Sydney Children's Hospital, Randwick; Discipline of Paediatrics and Child Health, University of New South Wales, Rural Medical School, Wagga Wagga; and Clinical Excellence Commission, Sydney, New South Wales, Australia.
John PreddyDepartment of Paediatrics, Sydney Children's Hospital, Randwick; Discipline of Paediatrics and Child Health, University of New South Wales, Rural Medical School, Wagga Wagga; and Clinical Excellence Commission, Sydney, New South Wales, Australia.
Sarah DaltonDepartment of Paediatrics, Sydney Children's Hospital, Randwick; Discipline of Paediatrics and Child Health, University of New South Wales, Rural Medical School, Wagga Wagga; and Clinical Excellence Commission, Sydney, New South Wales, Australia.
John ConnorsDepartment of Paediatrics, Sydney Children's Hospital, Randwick; Discipline of Paediatrics and Child Health, University of New South Wales, Rural Medical School, Wagga Wagga; and Clinical Excellence Commission, Sydney, New South Wales, Australia.
Sarah PattersonDepartment of Paediatrics, Sydney Children's Hospital, Randwick; Discipline of Paediatrics and Child Health, University of New South Wales, Rural Medical School, Wagga Wagga; and Clinical Excellence Commission, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGentamicin is an aminoglycoside antibiotic with broad-spectrum bactericidal activity and is widely used in pediatric units to treat infection with susceptible organisms. This study aimed to describe the dosage regimen for gentamicin and approach to its therapeutic drug monitoring (TDM) among the pediatric units within the state of New South Wales (NSW).

methodsA questionnaire was sent electronically to representatives of 40 pediatric units in NSW, requesting details of each unit's gentamicin dosing and TDM policy.

resultsA total of 35 units responded to the survey. The majority (63%) of the units used a dose of 7.5 mg/kg of gentamicin in patients with normal renal function. More than half of the units (54%) did not have a local gentamicin dosing protocol and relied on other sources for dosing regimens. Dosing responses varied from a dose of 6 mg/kg once daily for patients more than 10 years of age to 7 mg/kg once daily on day 1, followed by 5 mg/kg once daily for patients over 10 years of age. For TDM of gentamicin, 63% of units indicated use of trough levels and 23% units used the Hartford Nomogram.

conclusionsA significant variation exists in clinical practice among pediatric units in NSW on gentamicin dosing and TDM guidelines. There is an urgent need for collaboration among nursing, medical, and pharmacy experts to achieve consensus to develop and adopt statewide uniform guidelines on gentamicin dosing and TDM.

Identifiers

PMID30229154
PMCPMC6132910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.