Evidence map›Paper›PMID 30229136›Full record

ArticleeNeurologicalSci2018

Brain and spinal cord MRI lesions in primary progressive vs. relapsing-remitting multiple sclerosis.

Akram Dastagir, Brian C Healy, Alicia S Chua, Tanuja Chitnis, Howard L Weiner, Rohit Bakshi, Shahamat Tauhid

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeurologicalSci, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Peripartum disease activity in moderately and severely disabled women with multiple sclerosis.Multiple sclerosis journal - experimental, translational and clinical
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akram DastagirDepartments of Neurology and Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, USA.
Brian C HealyDepartments of Neurology and Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, USA.
Alicia S ChuaDepartments of Neurology and Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, USA.
Tanuja ChitnisDepartments of Neurology and Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, USA.
Howard L WeinerDepartments of Neurology and Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, USA.
Rohit BakshiDepartments of Neurology and Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, USA.
Shahamat TauhidDepartments of Neurology and Brigham and Women's Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary progressive (PP) multiple sclerosis (MS) is considered a clinically distinct entity from the spectrum of relapsing-remitting (RR) forms of the disease.

objectiveTo compare the presence of brain and spinal cord lesions between PP and RR subjects.

methodsWe studied people with PPMS [

resultsLesions in the brain only were less common in PP (

conclusionsWe report a topographic difference in MRI lesion involvement between PPMS and RRMS. Lesions restricted to the brain are more common in RRMS. These findings provide support to the notion that PP may have features distinctive from the RR spectrum of the disease. Longitudinal comparisons and quantitative MRI analysis would be necessary to confirm and extend these results.

Indexed as

BrainLesionsMRIMultiple sclerosisPrimary progressiveSpinal cord

Identifiers

PMID30229136
PMCPMC6141305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.