ArticleBioMed research international2018
Do Patients with Second Primary Colorectal Cancer Hold the Similar Prognosis and Therapeutic Benefits as Those with Initial Primary Colorectal Cancer?
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Second Primary Malignancies in Patients with Colorectal Cancer: The Frequency, Types, and Timeline.Journal of clinical medicine · 2026Article
- Deep learning-based predictive models for assessing the impact of clinical factors and second primary malignancy on survival in patients with colorectal cancer.European journal of medical research · 2025Article
- Prognosis and clinicopathological features of patients with early-onset and late-onset colorectal cancer with second primary malignancies.Journal of gastroenterology and hepatology · 2025Article
- Second primary colorectal cancer in adults: a SEER analysis of incidence and outcomes.BMC gastroenterology · 2023Article
- Colorectal cancer risk in association with colorectal cancer as a second malignancy in relatives: a nationwide cohort study.BMC cancer · 2022Article
- Risk of colon cancer-related death in people who had cancer in the past.International journal of colorectal disease · 2022Article
- Risk Factors on the Incidence and Prognostic Effects of Colorectal Cancer With Brain Metastasis: A SEER-Based Study.Frontiers in oncology · 2022Article
- Second primary malignancies in colorectal cancer patients.Scientific reports · 2021Article
- Prognosis and treatment differences between initial and second primary chondrosarcoma.Oncology letters · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe objective is to compare the differences on prognosis and the therapeutic benefits between initial and second primary colorectal cancer (pCRC).
methodsA dataset containing 377,271 initial pCRC cases and 18,617 second pCRC cases from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) 1988-2015 was evaluated. Survival comparisons were made using the log-rank test. Cox proportional hazards models were used to assess the survival benefits.
resultsThe cancer-specific survival rate of patients with initial pCRC was significantly higher than that of patients with second pCRC (5-years survival rate: 64.85% vs. 60.22%, P<0.001). The Chi-square of stratified log rank for age at diagnosis was lower than that for primary site, pTNM stage, sex, race, histology, and grade (Chi-square=86.73). There were almost no differences on therapeutic benefits between patients with initial and second pCRC except that treatments with chemotherapy were significantly associated with longer survival rate compared with treatments without chemotherapy among stage III surgical initial and second primary left-sided colon cancers patients (HR=0.764 vs. 0.581; P for interaction =0.008).
conclusionPatients with second pCRC have worse prognosis than those with initial pCRC primarily because of older age in the former group. The results evidenced that the therapeutic benefits on the prognosis for colorectal cancer were generally similar between patients with initial and second pCRC.
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