Evidence map›Paper›PMID 30228954›Full record

ArticleOncoimmunology

Non-thermal plasma induces immunogenic cell death

Abraham G Lin, Bo Xiang, Dante J Merlino, Trevor R Baybutt, Joya Sahu, Alexander Fridman, Adam E Snook, Vandana Miller

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Abraham G LinC. & J. Nyheim Plasma Institute, Drexel University, Camden, NJ, USA.
Bo XiangDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.
Dante J MerlinoDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9998-0579
Trevor R BaybuttDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.
Joya SahuCutaneous Lymphoma Center, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Alexander FridmanC. & J. Nyheim Plasma Institute, Drexel University, Camden, NJ, USA.
Adam E SnookDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9216-4560
Vandana MillerC. & J. Nyheim Plasma Institute, Drexel University, Camden, NJ, USA.
Thomas Jefferson University · USDrexel University · USThomas Jefferson University Hospital · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
Obesity Suppresses the GUCY2C endocrine Gut-Brain Axis Disrupting SatietyF30DK103492 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI MERLINO, DANTE · 2015 to 2016
$91k
NCI NIH HHS P30 CA056036NIDDK NIH HHS F30 DK103492
6 · The paper itself

Abstract

Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens. In the case of cancer therapy, tumor cells undergoing immunogenic death promote cancer-specific immunity. Identification, characterization, and optimization of stimuli that induce immunogenic cancer cell death has tremendous potential to improve the outcomes of cancer therapy. In this study, we show that non-thermal, atmospheric pressure plasma can be operated to induce immunogenic cell death in an animal model of colorectal cancer.

Indexed as

colorectal cancerimmunogenic cell deathNon-thermal plasmaplasma cancer immunotherapy

Identifiers

PMID30228954
PMCPMC6140551
OpenAlexW2808343073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.