Evidence map›Paper›PMID 30228930›Full record

ArticleOncoimmunology

Spillage of bacterial products during colon surgery increases the risk of liver metastases development in a rat colon carcinoma model.

Simran Grewal, Rianne Korthouwer, Marijn Bögels, Rens Braster, Niels Heemskerk, Andries E Budding, Stephan M Pouw, Jack van Horssen, Marjolein Ankersmit, Jeroen Meijerink and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Simran GrewalDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.ORCID 0000-0002-7377-8740
Rianne KorthouwerDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.
Marijn BögelsDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.ORCID 0000-0003-0882-7646
Rens BrasterDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.ORCID 0000-0002-4009-7877
Niels HeemskerkDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.ORCID 0000-0003-2340-537X
Andries E BuddingDepartment of Medical Microbiology and Infection Control, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Stephan M PouwDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.
Jack van HorssenDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.ORCID 0000-0003-4078-7402
Marjolein AnkersmitDepartment of Surgery, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Jeroen MeijerinkDepartment of Surgery, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Petrousjka van den TolDepartment of Surgery, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
Steven OosterlingDepartment of Surgery, Spaarne Gasthuis, PO Box 417, 2000 AK Haarlem, the Netherlands.
Jaap BonjerDepartment of Surgery, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.ORCID 0000-0002-9124-3483
Nuray GülDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.
Marjolein van EgmondDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.ORCID 0000-0001-6308-9266
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLSpaarne Gasthuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical resection of the primary tumor provides the best chance of cure for patients with colorectal carcinoma (CRC). However, bacterial translocation during intestinal surgery has been correlated with poor long-term oncological outcome. Therefore, we investigated the influence of bacterial contamination during colon surgery on CRC liver metastases development. Blood and liver samples of patients undergoing resection of primary CRC or liver metastases were collected. Cell numbers, activation markers and inflammatory mediators were determined. Tumor cell adhesion and outgrowth after sham- or colectomy operations were determined in a rat model, in which tumor cells had been injected into the portal vein. White blood cells and granulocytes were increased in per- and post-operative patient blood samples. IL-6 was also increased post-operatively compared to the preoperative level. Expression of NOX-2, NOX-4 and polymorphonuclear cells (PMNs) numbers were elevated in post-operative human liver samples.

Indexed as

bacterial translocationcolorectal tumor surgeryliver metastasesmacrophagesreactive oxygen species

Identifiers

PMID30228930
PMCPMC6140552
OpenAlexW2808955715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.