Evidence map›Paper›PMID 30228861›Full record

ReviewF1000Research2018

Recent advances in the understanding and management of oropharyngeal cancer.

Ashley Hay, Iain J Nixon

Abstract readReview
In one paragraph

Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Peritonsillar abscess as a clinical sign of oropharyngeal cancer - a Swedish national cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Trend of the Burden of Larynx Cancer in Brazil, 1990 to 2019.Revista da Sociedade Brasileira de Medicina Tropical · 2022
    Article
  11. Head and Neck Cancer Primary Tumor Auto Segmentation Using Model Ensembling of Deep Learning in PET/CT Images.Head and neck tumor segmentation and outcome prediction : second challenge, HECKTOR 2021, held in conjunction with MICCAI 2021, Strasbourg, France, September 27, 2021, Proceedings. Head and Neck Tumor Segmentation Challenge (2nd : 2021 ... · 2022
    Article
  12. Article
  13. Robotic surgery of head and neck cancers, a narrative review.European journal of translational myology · 2020
    Article
  14. Article
  15. Review
  16. Objective Selection Criteria between ALT and Radial Forearm Flap in Oral Soft Tissues Reconstruction.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2019
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ashley HayDepartment of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.ORCID 0000-0002-4666-836X
Iain J NixonDepartment of Otolaryngology Head and Neck Surgery, NHS Lothian, Edinburgh, UK.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing health problem in the developing and developed world. In recent years, there have been major changes in the treatment paradigms for OPSCC. This is because of a number of reasons: the understanding and discovery of a new viral etiology (the human papillomavirus [HPV]), changes in practice patterns owing to advances in radiotherapy, and then an organ preservation strategy with the increased use of chemotherapy. Next came the development of new surgical technologies and the emergence of a new treatment modality, immunotherapy. In this article, we discuss the evolution of OPSCC treatments, starting with the traditional tobacco era. Treatment paradigms then evolved during the organ preservation era, the HPV era, and the minimally invasive surgery era. We are currently in the immunotherapy era, with a number of new drugs becoming available both on trial and by approval for use in the clinical setting for head and neck cancer patients. We discuss a number of trials and the reasons behind attempts at both treatment escalation and treatment de-escalation.

Indexed as

Combined Modality TherapyDisease ManagementHumansOropharyngeal NeoplasmsPapillomaviridaePapillomavirus InfectionsImmunotherapyIMRTOropharynxRoboticsSquamous cell carcinoma

Identifiers

PMID30228861
PMCPMC6117847

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.