Evidence map›Paper›PMID 30228820›Full record

ArticleStem cells international2018

Efficient Promotion of Autophagy and Angiogenesis Using Mesenchymal Stem Cell Therapy Enhanced by the Low-Energy Shock Waves in the Treatment of Erectile Dysfunction.

Guan Qun Zhu, Seung Hwan Jeon, Woong Jin Bae, Sae Woong Choi, Hyun Cheol Jeong, Kang Sup Kim, Su Jin Kim, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. The Role of Autophagy in Erectile Dysfunction.The world journal of men's health · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Guan Qun ZhuDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.ORCID 0000-0001-7841-8026
Seung Hwan JeonDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Woong Jin BaeDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.ORCID 0000-0001-7703-1161
Sae Woong ChoiDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Hyun Cheol JeongDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kang Sup KimDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Su Jin KimDepartment of Urology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
Hyuk Jin ChoDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
U Syn HaDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sung Hoo HongDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ji Youl LeeDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Eun Bi KwonKEMIMEDI, Seoul, Republic of Korea.
Sae Woong KimDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.ORCID 0000-0002-9127-9400
Catholic University of Korea · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy with MSCT and ESWT in a rat model of diabetic ED. MATERIALS AND

methodsEight-week-old male Sprague-Dawley rats were randomly divided into 2 parts. Diabetic rats induced by streptozotocin (65 mg/kg) were randomly divided into 4 groups: (1) DM control group, (2) DM + ESWT group, (3) DM + MSCT group, and (4) DM + ESWT + MSCT group. The sham group was a normal control group (without streptozotocin). MSCT and (or) ESWT were, respectively, administered to each group according to the proposal for 8 weeks. Immediately after recording of intracavernous pressure (ICP), the penis was then harvested for histologic analysis, ELISA, and Western blotting.

resultsThe ratio of ICP/MAP was significantly higher in the DM + ESWT + MSCT group than in ESWT or MSCT treated group (

conclusionsCombination of LI-ESWT and MSCT can get a better result than a single treatment by expressing more VEGF which can take part in autophagy by triggering the PI3K/AKT/mTOR signaling pathway. This cooperative therapy would provide a new research direction in ED treatment for the future.

Identifiers

PMID30228820
PMCPMC6136471
OpenAlexW2889312210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.