ArticleScientific reports2018
Flow-induced platelet activation in components of the extracorporeal membrane oxygenation circuit.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Prolonged Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation in Sheep.Annals of biomedical engineering · 2026Article
- Protruding Objects in the Membrane Lung Outlet May Increase Thrombogenicity: Fluid Dynamical Insights.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Multimodal characterization of flow-induced thrombus initiation and growth in extracorporeal membrane oxygenation.Scientific reports · 2026Article
- A Deep Reinforcement Learning-Optimized Blood Flow Profile for Enhanced Oxygenation Efficiency in Membrane Oxygenators.Membranes · 2025Article
- Impact of adjustable resistance clamps on the in-vitro hemolysis assessment of blood pumps.Scientific reports · 2025Article
- Material-Induced Platelet Adhesion/Activation and Hemolysis of Membrane Lung Components from Extracorporeal Membrane Oxygenation.Biomedicines · 2025Article
- Right ventricular mechanical support as a bridge to lung transplantation: A literature review of current practices.JHLT open · 2025Review
- What Are the Best Biocompatible Materials for Extracorporeal Membrane Oxygenation.Journal of functional biomaterials · 2025Review
- Platelet Adhesion and Activation in an ECMO Thrombosis-on-a-Chip Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The impact of hypovolemia and PEEP on recirculation in venovenous ECMO: an experimental porcine model.Intensive care medicine experimental · 2024Article
- Effect of flow rate ratio and positioning on a lighthouse tip ECMO return cannula.Biomechanics and modeling in mechanobiology · 2023Article
- Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation.Blood advances · 2023Article
- Haematological Trends and Transfusion during Adult Extracorporeal Membrane Oxygenation: A Single Centre Study.Journal of clinical medicine · 2023Article
- The interplay of inflammation and coagulation in COVID-19 Patients receiving extracorporeal membrane oxygenation support.Perfusion · 2023Article
- Resistance valves in circulatory loops have a significant impact onFrontiers in physiology · 2023Article
- Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.Journal of biomechanical engineering · 2022Article
- Extracorporeal Membrane Oxygenation for Septic Shock in Children.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2022Article
- Estimating cardiac output based on gas exchange during veno-arterial extracorporeal membrane oxygenation in a simulation study using paediatric oxygenators.Scientific reports · 2021Article
- Evaluation of Anti-Activated Factor X Activity and Activated Partial Thromboplastin Time Relations and Their Association with Bleeding and Thrombosis during Veno-Arterial ECMO Support: A Retrospective Study.Journal of clinical medicine · 2021Article
- Conversion from Venovenous to Venoarterial Extracorporeal Membrane Oxygenation in Adults.Membranes · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracorporeal membrane oxygenation (ECMO) is used for rescue in severe respiratory and/or circulatory failure. The patient's blood is pumped over artificial surfaces in the ECMO circuit. A platelet activation model was applied to study the potential thrombogenicity of ECMO circuit components: the centrifugal blood pump, cannulae, and tubing connectors. Based on the accumulated effect of the scalar form of the stress acting on the platelet over time, the activation model enables assessment of platelet activation and pinpoints regions of elevated activation risk in a component. Numerical simulations of the flow in different components of the ECMO circuit was carried out where the activation level is a function of the impact of local stress and its history along the path that the platelets follow. The results showed that the pump carried the largest risk for platelet activation followed by the reinfusion cannula and lastly the connectors. Pump thrombogenicity was mainly due to long residence time and high shear-rate while the connector showed a high level of non-stationary shear-rate that in turn may contribute to the formation of aggregates through direct platelet activation or through high shear-rate modulation of the vWF multimers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.