Evidence map›Paper›PMID 30228313›Full record

ArticleScientific reports2018

The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice.

R Xing, A M Moerman, R Y Ridwan, K van Gaalen, E J Meester, A F W van der Steen, P C Evans, F J H Gijsen, K Van der Heiden

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Carotid artery plaque composition and distribution: near-infrared spectroscopy and intravascular ultrasound analysis.European heart journal supplements : journal of the European Society of Cardiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

R XingDepartment of Biomedical Engineering, Thorax center, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-2680-5117
A M MoermanDepartment of Biomedical Engineering, Thorax center, Erasmus University Medical Center, Rotterdam, The Netherlands.
R Y RidwanDepartment of Molecular Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
K van GaalenDepartment of Biomedical Engineering, Thorax center, Erasmus University Medical Center, Rotterdam, The Netherlands.
E J MeesterDepartment of Biomedical Engineering, Thorax center, Erasmus University Medical Center, Rotterdam, The Netherlands.
A F W van der SteenDepartment of Biomedical Engineering, Thorax center, Erasmus University Medical Center, Rotterdam, The Netherlands.
P C EvansDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
F J H GijsenDepartment of Biomedical Engineering, Thorax center, Erasmus University Medical Center, Rotterdam, The Netherlands.
K Van der HeidenDepartment of Biomedical Engineering, Thorax center, Erasmus University Medical Center, Rotterdam, The Netherlands. k.vanderheiden@erasmusmc.nl.
Erasmus MC · NLUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heart rate lowering drug Ivabradine was shown to improve cardiac outcome in patients with previous heart failure. However, in patients without heart failure, no beneficial effect of Ivabradine was observed. Animal studies suggested a preventive effect of Ivabradine on atherosclerosis which was due to an increase in wall shear stress (WSS), the blood flow-induced frictional force exerted on the endothelium, triggering anti-inflammatory responses. However, data on the effect of Ivabradine on WSS is sparse. We aim to study the effect of Ivabradine on (i) the 3D WSS distribution over a growing plaque and (ii) plaque composition. We induced atherosclerosis in ApoE

Indexed as

Disease Models, AnimalHemodynamicsAnimalsAtherosclerosisCardiovascular AgentsHeart RateIvabradineMaleMiceMice, Inbred C57BLMice, Knockout, ApoEPlaque, AtheroscleroticStress, MechanicalCardiovascular AgentsIvabradine

Identifiers

PMID30228313
PMCPMC6143553
OpenAlexW2891790983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.