Evidence map›Paper›PMID 30228264›Full record

ArticleNature communications2018

Olfactory receptor OR2AT4 regulates human hair growth.

Jérémy Chéret, Marta Bertolini, Leslie Ponce, Janin Lehmann, Teresa Tsai, Majid Alam, Hanns Hatt, Ralf Paus

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 132 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Olfactory receptors and human diseases.Cell and tissue research · 2025
    Review
  11. Article
  12. Frontal Fibrosing Alopecia: An Update.American journal of clinical dermatology · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review of sensory systems deployed by epidermal keratinocytes.Frontiers in cell and developmental biology · 2025
    Review
  18. Article
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jérémy ChéretMonasterium Laboratory, Skin and Hair Research Solutions GmbH, 48149, Münster, Germany.
Marta BertoliniMonasterium Laboratory, Skin and Hair Research Solutions GmbH, 48149, Münster, Germany.
Leslie PonceMonasterium Laboratory, Skin and Hair Research Solutions GmbH, 48149, Münster, Germany.
Janin LehmannMonasterium Laboratory, Skin and Hair Research Solutions GmbH, 48149, Münster, Germany.
Teresa TsaiDepartment of Cell Physiology, Faculty Biology and Biotechnology, Ruhr-University Bochum, 44801, Bochum, Germany.
Majid AlamMonasterium Laboratory, Skin and Hair Research Solutions GmbH, 48149, Münster, Germany.
Hanns HattDepartment of Cell Physiology, Faculty Biology and Biotechnology, Ruhr-University Bochum, 44801, Bochum, Germany.
Ralf PausCentre for Dermatology Research, MAHSC and NIHR Biomedical Research Centre, University of Manchester, Manchester, M13 9PT, UK. ralf.paus@manchester.ac.uk.
Monasterium Laboratory Skin & Hair Research Solutions (Germany) · DERuhr University Bochum · DENIHR Manchester Biomedical Research Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olfactory receptors are expressed by different cell types throughout the body and regulate physiological cell functions beyond olfaction. In particular, the olfactory receptor OR2AT4 has been shown to stimulate keratinocyte proliferation in the skin. Here, we show that the epithelium of human hair follicles, particularly the outer root sheath, expresses OR2AT4, and that specific stimulation of OR2AT4 by a synthetic sandalwood odorant (Sandalore

Indexed as

AdultAgedApoptosisButanolsCell ProliferationCyclopentanesEpitheliumGene Knockdown TechniquesHair FollicleHealthy VolunteersHumansInsulin-Like Growth Factor IKeratinocytesMiddle AgedOrgan Culture TechniquesReceptors, OdorantButanolsCyclopentanesIGF1 protein, humanInsulin-Like Growth Factor IOR2AT4 protein, humanpentamethylcyclopent-3-ene-butanolReceptors, OdorantRNA, Small Interfering

Identifiers

PMID30228264
PMCPMC6143528
OpenAlexW2889746315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.