Evidence map›Paper›PMID 30228242›Full record

ArticlemBio2018

Phosphorylation and Proteasome Recognition of the mRNA-Binding Protein Cth2 Facilitates Yeast Adaptation to Iron Deficiency.

Antonia M Romero, Mar Martínez-Pastor, Gang Du, Carme Solé, María Carlos, Sandra V Vergara, Nerea Sanvisens, James A Wohlschlegel, David P Toczyski, Francesc Posas and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Iron Regulatory Mechanisms inFrontiers in microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Antonia M RomeroDepartamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Paterna, Valencia, Spain.
Mar Martínez-PastorDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.
Gang DuDepartamento de Ciències Experimentals i de la Salut, Cell Signaling Research Group, Universitat Pompeu Fabra, Barcelona, Spain.
Carme SoléDepartamento de Ciències Experimentals i de la Salut, Cell Signaling Research Group, Universitat Pompeu Fabra, Barcelona, Spain.
María CarlosDepartamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Paterna, Valencia, Spain.
Sandra V VergaraDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.
Nerea SanvisensDepartment of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, California, USA.
David P ToczyskiDepartment of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
Francesc PosasDepartamento de Ciències Experimentals i de la Salut, Cell Signaling Research Group, Universitat Pompeu Fabra, Barcelona, Spain.
Eulàlia de NadalDepartamento de Ciències Experimentals i de la Salut, Cell Signaling Research Group, Universitat Pompeu Fabra, Barcelona, Spain.
María T Martínez-PastorDepartamento de Bioquímica y Biología Molecular, Universitat de València, Burjassot, Valencia, Spain.
Dennis J ThieleDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.
Sergi PuigDepartamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Paterna, Valencia, Spain spuig@iata.csic.es.
Duke University · USPompeu Fabra University · ESConsejo Superior de Investigaciones Científicas · ESInstituto de Agroquímica y Tecnología de Alimentos · ESTianjin University of Commerce · CNUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

Regulation by post-translation modifications in response to stressR35GM118104 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TOCZYSKI, DAVID PAUL · 2016 to 2025
$7.2M
Metal Homeostasis in YeastR01GM041840 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALSPAUGH, ANDREW · 1989 to 2022
$6.5M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Biogenesis of Extramitochondrial Iron-Sulfur Proteins in EukaryotesR01GM112763 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2015 to 2018
$982k
NIGMS NIH HHS R01 GM041840NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R01 GM112763NIGMS NIH HHS R35 GM118104
6 · The paper itself

Abstract

Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the world. Adaptation to iron limitation requires a global reorganization of the cellular metabolism directed to prioritize iron utilization for essential processes. In response to iron scarcity, the conserved

Indexed as

Adaptation, PhysiologicalGene Expression Regulation, FungalIronMutagenesisPhosphorylationProteasome Endopeptidase ComplexProtein Processing, Post-TranslationalProtein StabilityRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSerineTristetraprolinIronProteasome Endopeptidase ComplexRNA, MessengerSaccharomyces cerevisiae ProteinsSerineTIS11 protein, S cerevisiaeTristetraproliniron deficiencyphosphorylationposttranslational regulationprotein stabilityyeast

Identifiers

PMID30228242
PMCPMC6143738
OpenAlexW2891128871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.