ArticlemBio2018
Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.Briefings in bioinformatics · 2025Pooled it
- Pooled it
- REGULATION OF COLONIC MACROPHAGES AND TYPE-17 AND REGULATORY T CELLS IN DSS-COLITIS BY IBD-ASSOCIATED TRANSCRIPTION FACTOR, CREM.bioRxiv : the preprint server for biology · 2026Article
- Article
- Review
- Spatiotemporal Analysis of the Distribution of Waterborne Diseases in Children Under 5 Years of Age From 2018 to 2022 in the Lemba Health Zone in Kinshasa, DR Congo: A Retrospective and Observational Analysis.Health science reports · 2025Article
- The immunology of systemic lupus erythematosus.Nature immunology · 2024Review
- Integrated single-cell and bulk RNA sequencing reveals CREM is involved in the pathogenesis of ulcerative colitis.Heliyon · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Genome-Wide Association Studies of Diarrhea Frequency and Duration in the First Year of Life in Bangladeshi Infants.The Journal of infectious diseases · 2023Article
- Colitis caused by Entamoeba histolytica identified by real-time-PCR and fluorescence in situ hybridization from formalin-fixed, paraffin-embedded tissue.European journal of microbiology & immunology · 2022Article
- Host Genome-Wide Association Study of Infant Susceptibility toInfection and immunity · 2021Article
- Host Protective Mechanisms to Intestinal Amebiasis.Trends in parasitology · 2021Review
- Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria.Frontiers in cellular and infection microbiology · 2021Article
- Mucosal microbiota and gene expression are associated with long-term remission after discontinuation of adalimumab in ulcerative colitis.Scientific reports · 2020Article
- Entamoeba histolytica: Five facts about modeling a complex human disease in rodents.PLoS pathogens · 2020Article
- Identification of differentially expressed genes between the colon and ileum of patients with inflammatory bowel disease by gene co-expression analysis.The Journal of international medical research · 2020Article
- Observational
- Article
- Host-parasite interactions in infections due toTropical parasitologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 3 countries.
Genevieve L WojcikDepartment of Genetics, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-7206-8088
Chelsea MarieDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Mayuresh M AbhyankarDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Nobuya YoshidaDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Koji WatanabeDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Alexander J MentzerNuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Tommy CarstensenWellcome Trust Sanger Institute, Genome Campus, Oxford, United Kingdom.
Josyf MychaleckyjDepartment of Public Health Sciences, Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Beth D KirkpatrickVaccine Testing Center, University of Vermont College of Medicine, Burlington, Vermont, USA.
Stephen S RichDepartment of Public Health Sciences, Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Patrick ConcannonGenetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.
Rashidul HaqueInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
William A PetriDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Priya DuggalDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA pduggal@jhmi.edu.
University of Virginia · USBeth Israel Deaconess Medical Center · USCentre for Human Genetics · GBInternational Centre for Diarrhoeal Disease Research · BDJohns Hopkins University · USStanford University · USUniversity of Cambridge · GBUniversity of Florida · USUniversity of Vermont · US
Funding
VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2006 to 2011
$14.5MFIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7MVermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8MRole of CREM in Amebic Colitis and Inflammatory Bowel DiseaseR37AI026649 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2018 to 2026
$5.0MGene transcription in SLER37AI049954 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSOKOS, GEORGE C · 2013 to 2022
$4.8MNCRR NIH HHS P20 RR021905NIAID NIH HHS R01 AI043596NIAID NIH HHS R37 AI026649NIAID NIH HHS R37 AI049954NIGMS NIH HHS P30 GM118228Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genome-Wide Association StudyAllelesAnimalsChild, PreschoolCohort StudiesCullin ProteinsCyclic AMP Response Element ModulatorCyclinsDiarrheaDysentery, AmebicEntamoeba histolyticaEntamoebiasisFecesFemaleGastrointestinal TractGenetic Predisposition to DiseaseCCNY protein, humanCREM protein, humanCUL2 protein, humanCullin ProteinsCyclic AMP Response Element ModulatorCyclinsdiarrheaepidemiologygenomicsinfectious diseaseprotozoapublic health
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.