Evidence map›Paper›PMID 30228237›Full record

ArticlemBio2018

Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence.

Anna Nagel, Stephan Michalik, Michel Debarbouille, Tobias Hertlein, Manuela Gesell Salazar, Hermann Rath, Tarek Msadek, Knut Ohlsen, Jan Maarten van Dijl, Uwe Völker and 1 more

Abstract readComparative Study
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Interaction ofACS infectious diseases · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Inactivation ofFrontiers in microbiology · 2019
    Article
  17. Increasing virulence factors.Nature reviews. Microbiology · 2018
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna NagelInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Stephan MichalikInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Michel DebarbouilleBiology of Gram-Positive Pathogens, Department of Microbiology, Institut Pasteur and CNRS ERL 3526, Paris, France.
Tobias HertleinInstitute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany.
Manuela Gesell SalazarInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Hermann RathInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Tarek MsadekBiology of Gram-Positive Pathogens, Department of Microbiology, Institut Pasteur and CNRS ERL 3526, Paris, France.
Knut OhlsenInstitute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany.
Jan Maarten van DijlDepartment of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany voelker@uni-greifswald.de ulrike.maeder@uni-greifswald.de.
Ulrike MäderInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany voelker@uni-greifswald.de ulrike.maeder@uni-greifswald.de.ORCID 0000-0003-2873-0999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, BacterialTranscription Termination, GeneticAnimalsAnti-Bacterial AgentsBacteremiaBacterial ProteinsDisease Models, AnimalGene DeletionGene Expression ProfilingGenetic Complementation TestProtein KinasesProteomeRegulonRho FactorStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsProtein KinasesProteomeRho FactorSaeR protein, Staphylococcus aureusSaeS protein, Staphylococcus aureusTranscription FactorsVirulence Factorsantisense transcriptionbicyclomycinproteomeSaeRS TCSStaphylococcus aureustranscription termination

Identifiers

PMID30228237
PMCPMC6143737

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.