Evidence map›Paper›PMID 30228216›Full record

ArticleGut2019

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent.

John Broad, Victor W S Kung, Alexandra Palmer, Shezan Elahi, Azadeh Karami, Taher Darreh-Shori, Shafi Ahmed, Mohamed Adhnan Thaha, Rebecca Carroll, Joanne Chin-Aleong and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

John Broad *Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Victor W S Kung *Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Alexandra PalmerBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Shezan ElahiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Azadeh KaramiDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, NEO, Stockholm, Sweden.
Taher Darreh-ShoriDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, NEO, Stockholm, Sweden.
Shafi AhmedDepartment of Surgery, Barts Health NHS Trust, The Royal London Hospital, London, UK.
Mohamed Adhnan ThahaBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Rebecca CarrollBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Joanne Chin-AleongBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Joanne E MartinBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
M Jill SaffreySchool of Life, Health and Chemical Sciences, Open University, Milton Keynes, UK.
Charles H KnowlesBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Gareth John SangerBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-4231-1945
Queen Mary University of London · GBKarolinska Institutet · SEBarts Health NHS Trust · GBThe Open University · GB

Funding

The Dunhill Medical Trust R382/1114
6 · The paper itself

Abstract

objectiveTo determine if human colonic neuromuscular functions decline with increasing age.

designLooking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (cholinergic/nitrergic) contractions/relaxations in

resultsWith increasing age, EFS was more likely to evoke muscle relaxation in ascending colon instead of contraction (linear regression: n=109, slope 0.49%±0.21%/year, 95% CI), generally uninfluenced by comorbidity or use of medications. Similar changes were absent in descending colon. In the elderly, overall numbers of myenteric and neuronal nitric oxide synthase-immunoreactive neurons and intramuscular nerve densities were unchanged in ascending and descending colon, compared with adults. In elderly ascending, not descending, colon numbers of cell bodies exhibiting choline acetyltransferase immunoreactivity increased compared with adults (5.0±0.6 vs 2.4±0.3 neurons/mm myenteric plexus, p=0.04). Cholinergically mediated contractions were smaller in elderly ascending colon compared with adults (2.1±0.4 and 4.1±1.1 g-tension/g-tissue during EFS; n=25/14; p=0.04); there were no changes in nitrergic function or in ability of the muscle to contract/relax. Similar changes were absent in descending colon.

conclusionIn ascending not descending colon, ageing impairs cholinergic function.

Indexed as

AdultAgedAged, 80 and overAge FactorsColon, AscendingColon, DescendingElectric StimulationFemaleHumansMaleMiddle AgedMuscle ContractionNerve FibersNeural PathwaysNeuromuscular JunctionTissue Culture Techniquesageingaxon transportcholine acetyltransferasecolonhuman

Identifiers

PMID30228216
PMCPMC6594449
OpenAlexW2889974898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.