Evidence map›Paper›PMID 30228197›Full record

ArticleGenetics2018

The mTOR Target S6 Kinase Arrests Development in

Peter Chisnell, T Richard Parenteau, Elizabeth Tank, Kaveh Ashrafi, Cynthia Kenyon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Quetiapine Shortens the Lifespan ofInternational journal of molecular sciences · 2022
    Article
  4. Review
  5. TOR Signaling inGenetics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Peter ChisnellDepartment of Biochemistry and Biophysics, University of California, San Francisco, California 94158.ORCID 0000-0003-4923-6789
T Richard ParenteauDepartment of Biochemistry and Biophysics, University of California, San Francisco, California 94158.
Elizabeth TankDepartment of Neurology, University of Michigan, Ann Arbor, Michigan 48109.
Kaveh AshrafiDepartment of Physiology, University of California, San Francisco, California 94158.
Cynthia KenyonDepartment of Biochemistry and Biophysics, University of California, San Francisco, California 94158 cynthia@calicolabs.com.
University of California, San Francisco · USUniversity of Michigan–Ann Arbor · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Linking metabolism, neural function, and agingR01AG046400 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHRAFI, KAVEH · 2014 to 2023
$4.3M
Genetic Control of Aging in C. elegansR37AG011816 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KENYON, CYNTHIA J. · 2004 to 2013
$3.6M
GENETIC ANALYSIS OF AGING IN C ELEGANSR01AG011816 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHRAFI, KAVEH · 1994 to 2018
$3.6M
NIA NIH HHS R01 AG011816NIA NIH HHS R01 AG046400NIA NIH HHS R37 AG011816NIH HHS P40 OD010440
6 · The paper itself

Abstract

The widely conserved heat-shock response, regulated by heat-shock transcription factors, is not only essential for cellular stress resistance and adult longevity, but also for proper development. However, the genetic mechanisms by which heat-shock transcription factors regulate development are not well understood. In

Indexed as

Gene DeletionAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsRibosomal Protein S6 Kinases, 70-kDaTOR Serine-Threonine KinasesTranscription FactorsCaenorhabditis elegans Proteinsheat shock factor-1, C elegansRibosomal Protein S6 Kinases, 70-kDaRsks-1 protein, C elegansTOR Serine-Threonine KinasesTranscription FactorsC. elegansdevelopmentdevelopmental arrestheat shock factormTORribosomal S6 kinasetranslationWormBase

Identifiers

PMID30228197
PMCPMC6218238
OpenAlexW2900113746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.