Evidence map›Paper›PMID 30228189›Full record

ArticleThe Journal of biological chemistry2018

Thumb domains of the three epithelial Na

Shaohu Sheng, Jingxin Chen, Anindit Mukherjee, Megan E Yates, Teresa M Buck, Jeffrey L Brodsky, Michael A Tolino, Rebecca P Hughey, Thomas R Kleyman

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Acid-sensing ion channel 2a assembles with epithelial NaThe Journal of biological chemistry · 2026
    Article
  2. Epithelial NaComprehensive Physiology · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Analyses of epithelial NaThe Journal of biological chemistry · 2019
    Article
  7. The epithelial NaThe Journal of biological chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shaohu ShengFrom the Renal-Electrolyte Division, Department of Medicine and.ORCID 0000-0002-7198-1702
Jingxin ChenFrom the Renal-Electrolyte Division, Department of Medicine and.
Anindit MukherjeeFrom the Renal-Electrolyte Division, Department of Medicine and.
Megan E Yatesthe Departments of Biological Sciences.
Teresa M Buckthe Departments of Biological Sciences.
Jeffrey L Brodskythe Departments of Biological Sciences.
Michael A TolinoFrom the Renal-Electrolyte Division, Department of Medicine and.
Rebecca P HugheyFrom the Renal-Electrolyte Division, Department of Medicine and.
Thomas R KleymanFrom the Renal-Electrolyte Division, Department of Medicine and kleyman@pitt.edu.ORCID 0000-0002-2413-5415

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Biomechanical Regulation of Renal Ion TransportersR37DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2006 to 2015
$3.2M
ER Associated Degradation of Membrane Proteins in YeastR01GM075061 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L. · 2006 to 2019
$3.2M
SODIUM CHANNELS IN THE MAMMALIAN URINARY BLADDERR01DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R. · 1996 to 2005
$1.5M
Characterization of the ER associated Biogenesis and Degradation of ENaCK01DK090195 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCK, TERESA M · 2011 to 2015
$497k
Investigating the role of GRP170 in ENaC biogenesisR03DK109024 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCK, TERESA M · 2016 to 2017
$154k
NIDDK NIH HHS K01 DK090195NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK051391NIDDK NIH HHS R03 DK109024NIDDK NIH HHS R37 DK051391NIGMS NIH HHS R01 GM075061
6 · The paper itself

Abstract

The epithelial Na

Indexed as

ProteolysisAnimalsEpithelial Sodium ChannelsGene ExpressionHumansOocytesProtein DomainsProtein SubunitsXenopus laevisEpithelial Sodium ChannelsProtein Subunitsacid sensing ion channel (ASIC)amiloridechannel gatingepithelial sodium channel (ENaC)ion channelprotein denaturationprotein domainself-inhibition

Identifiers

PMID30228189
PMCPMC6231141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.