Evidence map›Paper›PMID 30228182›Full record

ArticleThe Journal of biological chemistry2018

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.

Suresh K Joseph, Michael P Young, Kamil Alzayady, David I Yule, Mehboob Ali, David M Booth, György Hajnóczky

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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  6. Review
  7. Molecular Determinants of TMC Protein Biogenesis and Trafficking.International journal of molecular sciences · 2025
    Article
  8. Review
  9. Redox regulation of UPR signalling and mitochondrial ER contact sites.Cellular and molecular life sciences : CMLS · 2024
    Review
  10. Photocatalytic manipulation of CaScience advances · 2024
    Article
  11. Article
  12. ZneLife · 2023
    Article
  13. ZnbioRxiv : the preprint server for biology · 2023
    Article
  14. Review
  15. Article
  16. Dysregulated CaCells · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. CaFrontiers in cellular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Suresh K JosephFrom the MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, suresh.joseph@jefferson.edu.
Michael P YoungFrom the MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Kamil Alzayadythe Department of Pharmacology & Physiology, University of Rochester, Rochester, New York 14642, and.
David I Yulethe Department of Pharmacology & Physiology, University of Rochester, Rochester, New York 14642, and.ORCID 0000-0002-6743-0668
Mehboob Alithe Center for Perinatal Research, Research Institute, Nationwide Children's Hospital, Columbus, Ohio 43205.
David M BoothFrom the MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
György HajnóczkyFrom the MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Thomas Jefferson University · USUniversity of Rochester · USNationwide Children's Hospital · US

Funding

Mechanisms of Pulsatile Calcium SignalingR01DK051526 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI HAJNOCZKY, GYORGY · 2001 to 2016
$4.3M
Study of the mitochondrial-cellular response to environmental stress by flourescence imagingR33ES025672 · NIEHS · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, HAJNOCZKY, GYORGY · 2017 to 2019
$1.5M
Redox Regulation of Intracellular Calcium SignalingR01DK103558 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI HAJNOCZKY, GYORGY, JOSEPH, SURESH K · 2015 to 2018
$1.4M
MECHANISMS OF PULSATILE CALCIUM SIGNALINGR29DK051526 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI HAJNOCZKY, GYORGY · 1996 to 2000
$121k
NIDDK NIH HHS R01 DK051526NIDDK NIH HHS R01 DK103558NIDDK NIH HHS R29 DK051526NIEHS NIH HHS R33 ES025672
6 · The paper itself

Abstract

A sensitization of inositol 1,4,5-trisphosphate receptor (IP

Indexed as

Amino Acid SubstitutionCalcium SignalingCysteineHEK293 CellsHumansHydrogen PeroxideInositol 1,4,5-Trisphosphate ReceptorsOxidation-ReductionCysteineHydrogen PeroxideInositol 1,4,5-Trisphosphate Receptorscalcium channelcalcium intracellular releasecalcium transportendoplasmic reticulum (ER)inositol 1,4,5-trisphosphate (IP3)inositol 1,4,5-trisphosphate receptoroxidative stressproteomicsredox regulationredox-sensitive cysteine

Identifiers

PMID30228182
PMCPMC6231128
OpenAlexW2890251899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.