ArticleThe Journal of cell biology2018
Occluding junctions as novel regulators of tissue mechanics during wound repair.
Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Epithelial Layer Fluidization by Curvature-Induced Unjamming.Physical review letters · 2025Article
- A role for Myo-II zipper and spaghetti squash in Gliotactin-dependent Drosophila melanogaster wing hair planar cell polarity.PloS one · 2025Article
- microRNA-184 distribution and consequences on glial septate junctions and the blood-brain barrier.PloS one · 2025Article
- Article
- Severe Burn Injury Significantly Alters the Gene Expression and m6A Methylation Tagging of mRNAs and lncRNAs in Human Skin.Journal of personalized medicine · 2023Article
- Septate junction proteins are required for cell shape changes, actomyosin reorganization and cell adhesion during dorsal closure inFrontiers in cell and developmental biology · 2022Article
- Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells.Scientific reports · 2021Article
- Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development.Journal of developmental biology · 2021Review
- Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing.Biology open · 2020Article
- Polarity during tissue repair, a multiscale problem.Current opinion in cell biology · 2020Review
- Casein kinase 1α decreases β-catenin levels at adherens junctions to facilitate wound closure inDevelopment (Cambridge, England) · 2019Article
- Forceful closure: cytoskeletal networks in embryonic wound repair.Molecular biology of the cell · 2019Review
- Atypical septate junctions maintain the somatic enclosure around maturing spermatids and prevent premature sperm release inBiology open · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In epithelial tissues, cells tightly connect to each other through cell-cell junctions, but they also present the remarkable capacity of reorganizing themselves without compromising tissue integrity. Upon injury, simple epithelia efficiently resolve small lesions through the action of actin cytoskeleton contractile structures at the wound edge and cellular rearrangements. However, the underlying mechanisms and how they cooperate are still poorly understood. In this study, we combine live imaging and theoretical modeling to reveal a novel and indispensable role for occluding junctions (OJs) in this process. We demonstrate that OJ loss of function leads to defects in wound-closure dynamics: instead of contracting, wounds dramatically increase their area. OJ mutants exhibit phenotypes in cell shape, cellular rearrangements, and mechanical properties as well as in actin cytoskeleton dynamics at the wound edge. We propose that OJs are essential for wound closure by impacting on epithelial mechanics at the tissue level, which in turn is crucial for correct regulation of the cellular events occurring at the wound edge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.