Evidence map›Paper›PMID 30228121›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization.

Robert A Rifkin, Deborah Huyghe, Xiaofan Li, Manasa Parakala, Erin Aisenberg, Stephen J Moss, Paul A Slesinger

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. NAcLat-DBS reduces GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022
    Review
  8. GABACurrent topics in behavioral neurosciences · 2022
    Article
  9. Article
  10. Review
  11. Advances in Targeting GIRK Channels in Disease.Trends in pharmacological sciences · 2021
    Review
  12. Lipid Rafts and Dopamine Receptor Signaling.International journal of molecular sciences · 2020
    Review
  13. Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  14. Article
  15. Direct Interaction of PP2A Phosphatase with GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  16. GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  17. Novel and Potent Dopamine DACS pharmacology & translational science · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Robert A RifkinDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Deborah HuygheDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02155.
Xiaofan LiDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Manasa ParakalaDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02155.
Erin AisenbergDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02155.
Paul A SlesingerDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029; paul.slesinger@mssm.edu.ORCID 0000-0002-3868-7528
Allen Institute for Brain Science · USTufts University · US

Funding

Structural Analysis of Alcohol-dependent Activation of GIRKsR01AA018734 · NIAAA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Paul A Slesinger · 2010 to 2026
$6.6M
Teaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2M
Modulation of KCC2 activity and the postnatal development of synaptic inhibitionR01NS101888 · NINDS · TUFTS UNIVERSITY BOSTON · PI DEEB, TAREK ZIAD, MOSS, STEPHEN J · 2017 to 2021
$2.3M
Dissecting Mechanisms of GABAB-GIRK Plasticity with PsychostimulantsR01DA037170 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSS, STEPHEN J, SLESINGER, PAUL A · 2014 to 2018
$2.1M
Deficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0M
Deficits in KCC2 activity and the pathophysiology of Autism spectrum disordersR21MH106954 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2015 to 2016
$454k
Behavioral effects, and molecular- and circuit-level mechanisms, of sorting nexin 27 (SNX27) regulation of GIRK channelsF30DA039637 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RIFKIN, ROBERT · 2016 to 2017
$82k
NIAAA NIH HHS R01 AA018734NIDA NIH HHS F30 DA039637NIDA NIH HHS R01 DA037170NIGMS NIH HHS T32 GM062754NIMH NIH HHS R21 MH106954NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS101888
6 · The paper itself

Abstract

GABA

Indexed as

AnimalsCocaineCocaine-Related DisordersDopaminergic NeuronsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsLocomotionMiceMice, KnockoutReceptors, Dopamine D2Sorting NexinsCocainedopamine D2L receptorG Protein-Coupled Inwardly-Rectifying Potassium ChannelsReceptors, Dopamine D2Snx27 protein, mouseSorting Nexinsaddictiondopaminepotassium channelpsychostimulantsventral tegmental area

Identifiers

PMID30228121
PMCPMC6176583
OpenAlexW2891362397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.