ArticleProceedings of the National Academy of Sciences of the United States of America2018
Genomic responses to selection for tame/aggressive behaviors in the silver fox (
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 102 citations in OpenAlex.
- Chemogenetic activation of the amygdala core nucleus increases aggression in chickens.iScience · 2026Article
- Gut microbiome community structure correlates with different behavioral phenotypes in the Belyaev Farm-Fox Experiment.Communications biology · 2026Article
- Using Whole-Genome Sequencing Data Reveals the Population Structure and Selection Signatures for Reproduction Traits in Duolang Sheep.Animals : an open access journal from MDPI · 2025Article
- Coexisting With Humans: Genomic and Behavioral Consequences in a Small and Isolated Bear Population.Molecular biology and evolution · 2025Article
- Linking individual fitness to the evolution of cognition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Rewilded horses in European nature conservation - a genetics, ethics, and welfare perspective.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Topography of violent intraspecific aggression in a subset of dogs from directionally selected lines of Canis familiaris.PloS one · 2025Article
- A Principal Components Analysis and Functional Annotation of Differentially Expressed Genes in Brain Regions of Gray Rats Selected for Tame or Aggressive Behavior.International journal of molecular sciences · 2024Article
- A missense mutation inScience advances · 2023Article
- The brain of the silver fox (Vulpes vulpes): a neuroanatomical reference of cell-stained histological and MRI images.Brain structure & function · 2023Article
- Defining hippocampal area CA2 in the fox (Vulpes vulpes) brain.Hippocampus · 2023Article
- What made us "hunter-gatherers of words".Frontiers in neuroscience · 2023Article
- Article
- Comparison of behavioural tendencies between "dangerous dogs" and other domestic dog breeds - Evolutionary context and practical implications.Evolutionary applications · 2022Article
- Identification of functional single nucleotide polymorphisms in the porcine SLC6A4 gene associated with aggressive behavior in weaned pigs after mixing.Journal of animal science · 2022Article
- Genetic diversity and population structure of six autochthonous pig breeds from Croatia, Serbia, and Slovenia.Genetics, selection, evolution : GSE · 2022Article
- Association between host genetics of sheep and the rumen microbial composition.Tropical animal health and production · 2022Article
- Article
- The olfactory limbus of the red fox (Frontiers in neuroanatomy · 2022Article
- Human-modified canids in human-modified landscapes: The evolutionary consequences of hybridization for grey wolves and free-ranging domestic dogs.Evolutionary applications · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Animal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more than 50 generations at the Institute for Cytology and Genetics in Novosibirsk, Russia. To understand the genetic basis and molecular mechanisms underlying the phenotypic changes, we profiled gene expression levels and coding SNP allele frequencies in two brain tissue specimens from 12 aggressive foxes and 12 tame foxes. Expression analysis revealed 146 genes in the prefrontal cortex and 33 genes in the basal forebrain that were differentially expressed, with a 5% false discovery rate (FDR). These candidates include genes in key pathways known to be critical to neurologic processing, including the serotonin and glutamate receptor pathways. In addition, 295 of the 31,000 exonic SNPs show significant allele frequency differences between the tame and aggressive populations (1% FDR), including genes with a role in neural crest cell fate determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.