ArticleProceedings of the National Academy of Sciences of the United States of America2018
Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Genome-guided discovery of antibiotic activity iniScience · 2026Article
- Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products.Natural product reports · 2025Review
- Harnessing emergent properties of microbial consortia for Agriculture: Assembly of the Xilonen SynCom.Biofilm · 2025Article
- Identification of essential genes by transposon insertion sequencing and genome-scale metabolic model construction inMicrobiology spectrum · 2025Article
- Current Approaches and Implications in Discovery of Novel Bioactive Products from Microbial Sources.Current microbiology · 2025Review
- Skin microbiome and dermatologic disorders.The Journal of clinical investigation · 2025Review
- Comprehensive In Vitro Evaluation of Antibacterial, Antioxidant, and Computational Insights intoPlants (Basel, Switzerland) · 2024Article
- Genus-specific secondary metabolome inSynthetic and systems biotechnology · 2024Article
- Biosynthesis of isonitrile lipopeptides.Current opinion in chemical biology · 2024Review
- Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes.Chemical science · 2024Article
- Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin.Journal of the American Chemical Society · 2024Article
- Oxidative stress is intrinsic to staphylococcal adaptation to fatty acid synthesis antibiotics.iScience · 2024Article
- Structural and functional characterization of FabG4 from Mycolicibacterium smegmatis.Acta crystallographica. Section F, Structural biology communications · 2024Article
- Crystal structures of the fatty acid biosynthesis initiation enzymes in Bacillus subtilis.Journal of structural biology · 2024Article
- Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action.Antibiotics (Basel, Switzerland) · 2023Review
- Multi-omics Data Reveal the Effect of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces.Genomics, proteomics & bioinformatics · 2023Article
- Genomic Insights into the Microbial AgentMicroorganisms · 2023Article
- Microbiome-Mediated Protection against Pathogens in Woody Plants.International journal of molecular sciences · 2023Review
- Microbial Biofilms for Environmental Bioremediation of Heavy Metals: a Review.Applied biochemistry and biotechnology · 2023Review
- Natural Algaecide Sphingosines Identified in Hybrid Straw Decomposition Driven by White-Rot Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The rapid emergence of antibiotic-resistant pathogenic bacteria has accelerated the search for new antibiotics. Many clinically used antibacterials were discovered through culturing a single microbial species under nutrient-rich conditions, but in the environment, bacteria constantly encounter poor nutrient conditions and interact with neighboring microbial species. In an effort to recapitulate this environment, we generated a nine-strain actinomycete community and used 16S rDNA sequencing to deconvolute the stochastic production of antimicrobial activity that was not observed from any of the axenic cultures. We subsequently simplified the community to just two strains and identified
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.