Evidence map›Paper›PMID 30228103›Full record

ArticleDevelopment (Cambridge, England)2018

Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.

Joel M Brown, María J García-García

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. A lateral tension model for mouse cranial neural tube closure.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. Multifaceted control of T cell differentiation by STIM1.Trends in biochemical sciences · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Cofilin Signaling in the CNS Physiology and Neurodegeneration.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases.International journal of molecular sciences · 2021
    Review
  12. Primary Active CaCold Spring Harbor perspectives in biology · 2020
    Review
  13. Mechanisms of 3D cell migration.Nature reviews. Molecular cell biology · 2019
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joel M BrownDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
María J García-GarcíaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA garciamj@cornell.edu.ORCID 0000-0003-0942-6238
Cornell University · US

Funding

Acquisition of a Nano Computed Tomography Instrument for shared Cornell Imaging fS10OD012287 · OD · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2013 to 2013
$755k
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025502NIH HHS S10 OD012287
6 · The paper itself

Abstract

Neural tube closure relies on the apical constriction of neuroepithelial cells. Research in frog and fly embryos has found links between the levels of intracellular calcium, actomyosin dynamics and apical constriction. However, genetic evidence for a role of calcium in apical constriction during mammalian neurulation is still lacking. Secretory pathway calcium ATPase (SPCA1) regulates calcium homeostasis by pumping cytosolic calcium into the Golgi apparatus. Loss of function in

Indexed as

Secretory PathwayActin CytoskeletonAllelesAmino Acid SequenceAnimalsApoptosisBase SequenceCalciumCalcium-Transporting ATPasesCofilin 1CytoskeletonFemaleGenetic TestingHomeostasisMaleMice, Inbred C57BLCalciumCalcium-Transporting ATPasesCofilin 1Myosin Type IIApical constrictionAtp2c1Ca2+Cofilin 1MouseNeural tube closureNon-muscle myosin II

Identifiers

PMID30228103
PMCPMC6514415
OpenAlexW2890800289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.