ArticleBiological psychiatry2018
The Functional Connectivity Between the Nucleus Accumbens and the Ventromedial Prefrontal Cortex as an Endophenotype for Bipolar Disorder.
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.Biomolecules · 2022Pooled it
- Large-scale network dysfunction in the acute state compared to the remitted state of bipolar disorder: A meta-analysis of resting-state functional connectivity.EBioMedicine · 2020Pooled it
- Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment.Molecular psychiatry · 2025Trial
- Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Long-Term Efficacy and Resting-State Functional Magnetic Resonance Imaging Changes of Deep Brain Stimulation in the Lateral Habenula Nucleus for Treatment-Resistant Bipolar Disorder.Brain and behavior · 2025Article
- Changes in ventral prefrontal-subcortical network connectivity during the course of remission from bipolar mania.Journal of mood and anxiety disorders · 2025Article
- Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Enhancing Speech Rehabilitation in a Young Adult with Trisomy 21: Integrating Transcranial Direct Current Stimulation (tDCS) with Rapid Syllable Transition Training for Apraxia of Speech.Brain sciences · 2024Article
- Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive predictive value.Communications biology · 2023Article
- Brain-based graph-theoretical predictive modeling to map the trajectory of transdiagnostic symptoms of anhedonia, impulsivity, and hypomania from the human functional connectome.Research square · 2023Article
- Atypical antipsychotics antagonize GABAMolecular psychiatry · 2023Article
- Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.CNS neuroscience & therapeutics · 2023Article
- Conceptualizing psychological resilience through resting-state functional MRI in a mentally healthy population: a systematic review.Frontiers in behavioral neuroscience · 2023Review
- The positive and negative emotion functions related to loneliness: a systematic review of behavioural and neuroimaging studies.Psychoradiology · 2023Review
- Altered functional connectivity of nucleus accumbens subregions associates with non-motor symptoms in Parkinson's disease.CNS neuroscience & therapeutics · 2022Article
- Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder.Translational psychiatry · 2022Article
- Alterations in resting-state whole-brain functional connectivity pattern similarity in bipolar disorder patients.Brain and behavior · 2022Article
- Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study.European archives of psychiatry and clinical neuroscience · 2021Article
- Cortical thinning and associated connectivity changes in patients with anorexia nervosa.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAlterations in functional connectivity between the nucleus accumbens (NAcc) and frontal cortices have been previously associated with the presence of psychiatric syndromes, including bipolar disorder (BD). Whether these alterations are a consequence or a risk factor for mental disorders remains unresolved.
methodsThis study included 35 patients with BD, 30 nonaffected siblings of patients with BD, and 23 healthy control subjects to probe functional connectivity at rest between NAcc and the rest of the brain in a cross-sectional design. Blood oxygen level-dependent time series at rest from NAcc were used as seed region in a voxelwise correlational analysis. The strength of the correlations found was compared across groups after Fisher's Z transformation.
resultsWe found increased functional connectivity between the NAcc and the ventromedial prefrontal cortex-comprising mainly the subgenual anterior cingulate-in patients compared with healthy control subjects. Participants at increased genetic risk but yet resilient-nonaffected siblings-showed functional connectivity values midway between the former two groups.
conclusionsOur results are indicative of the potential for the connectivity between NAcc and the ventromedial prefrontal cortex to represent an endophenotype for BD.
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