Evidence map›Paper›PMID 30227902›Full record

ArticleComparative medicine2018

Allograft Inflammatory Factor 1 as an Immunohistochemical Marker for Macrophages in Multiple Tissues and Laboratory Animal Species.

Kathleen M Donovan, Mariah R Leidinger, Logan P McQuillen, J Adam Goeken, Christine M Hogan, Sailesh C Harwani, Heather A Flaherty, David K Meyerholz

Abstract read
In one paragraph

Article in Comparative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in immunology · 2026
    Article
  4. Article
  5. Review
  6. Microorganisms · 2025
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kathleen M DonovanOffice of Animal Resources, University of Iowa, Iowa City, Iowa, USA.
Mariah R LeidingerDepartments of Pathology, University of Iowa, Iowa City, Iowa, USA.
Logan P McQuillenDepartments of Pathology, University of Iowa, Iowa City, Iowa, USA.
J Adam GoekenDepartments of Pathology, University of Iowa, Iowa City, Iowa, USA.
Christine M HoganDepartments of Pathology, University of Iowa, Iowa City, Iowa, USA.
Sailesh C HarwaniDepartments of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Heather A FlahertyDepartment of Veterinary Pathology, Iowa State University, Ames, Iowa, USA.
David K MeyerholzDepartments of Pathology, University of Iowa, Iowa City, Iowa, USA. david-meyerholz@uiowa.edu.
University of Iowa · USIowa State University · US

Funding

Vector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 1993 to 2019
$36.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Allograft inflammatory factor 1 (AIF1) is a commonly used marker for microglia in the brains of humans and some animal models but has had limited applications elsewhere. We sought to determine whether AIF1 can be used as a macrophage marker across common laboratory animal species and tissues. We studied tissues (that is, spleen, liver, and lung) with defined macrophage populations by using an AIF1 immunostaining technique previously validated in human tissue. Tissues were collected from various mouse strains (

Indexed as

AnimalsBiomarkersCalcium-Binding ProteinsDNA-Binding ProteinsFerretsHumansImmunohistochemistryMacrophagesMiceMicrofilament ProteinsRatsSpecies SpecificitySwineAIF1 protein, humanAif1 protein, mouseAif1 protein, ratBiomarkersCalcium-Binding ProteinsDNA-Binding ProteinsMicrofilament Proteins

Identifiers

PMID30227902
PMCPMC6200031
OpenAlexW2890740349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.