ArticleRadiation oncology (London, England)2018
Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation.
Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 29 citations in OpenAlex.
- Total body irradiation across conditioning intensities: historical context, dose-fractionation strategy, and the role of the chemotherapy backbone.Bone marrow transplantation · 2026Article
- Paired dosimetric comparison of VMAT-based total body and total marrow irradiation in adult leukemia patients: enhanced organ sparing with consistent plan complexity.Frontiers in oncology · 2026Article
- The implementation of low instantaneous dose rate total body irradiation with linear accelerator in small-size treatment rooms.Journal of applied clinical medical physics · 2024Article
- Total body irradiation: A transition from a Co-60 treatment unit to an IMRT lateral-field extended-SAD technique.Journal of applied clinical medical physics · 2024Article
- Considerations for intensity modulated total body or total marrow and lymphoid irradiation.Clinical and translational radiation oncology · 2023Article
- Analysis of long-term mortality after total body irradiation-based and melphalan-based chemotherapy conditioning for acute myeloid leukemia.Annals of hematology · 2023Article
- A case of malignant mesothelioma in a young patient with childhood leukaemia who had received total body irradiation.Oxford medical case reports · 2023Article
- Two compound techniques for total body irradiation.Technical innovations & patient support in radiation oncology · 2022Article
- Total body irradiation for standard treatment rooms: a robust sweeping beam technique with respect to the body shape.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Article
- Image-guided volumetric-modulated arc therapy of total body irradiation: An efficient workflow from simulation to delivery.Journal of applied clinical medical physics · 2021Article
- Article
- Pulmonary Toxicity After Total Body Irradiation - Critical Review of the Literature and Recommendations for Toxicity Reporting.Frontiers in oncology · 2021Review
- The safety and efficacy of a novel hypo-fractionated total marrow and lymphoid irradiation before allogeneic stem cell transplantation for lymphoma and acute leukemia.Clinical and translational radiation oncology · 2021Article
- Standardized flattening filter free volumetric modulated arc therapy plans based on anteroposterior width for total body irradiation.Journal of applied clinical medical physics · 2020Article
- Novel rotatable tabletop for total-body irradiation using a linac-based VMAT technique.Radiation oncology (London, England) · 2019Article
- Effect of changes in monitor unit rate and energy on dose rate of total marrow irradiation based on Linac volumetric arc therapy.Radiation oncology (London, England) · 2019Article
- Dosimetric Performance Analysis of Pediatric Based Halcyon™ Volumetric Arc Therapy-Based Lung-Sparing Total Body Irradiation.Technology in cancer research & treatmentArticle
- Adverse Effects of Total Body Irradiation: A Two-Decade, Single Institution Analysis.Advances in radiation oncologyArticle
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Authors and funding
6 authors at 1 institution in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study evaluated the effect of radiation dose rate in patients with hematolymphoid malignancies undergoing myeloablative conditioning with total body irradiation (TBI), for hematopoietic stem cell transplantation.
methodsThe incidence of pulmonary toxicity (PT) and treatment efficacy were compared between the conventional (≥ 6 cGy/min) and reduced dose rate (< 6 cGy/min). Seventy-seven patients receiving once-daily TBI between 2000 and 2016 were reviewed. We compared the cumulative rate of PT, overall survival (OS), relapse, and transplantation-related mortality (TRM) between conventional (n = 54) and reduced (n = 23) groups. Factors associated with PT were assessed in the presence of competing risks.
resultsThe median follow-up time was 40.7 months, and PT occurred in 50 patients (64.9%). On multivariate analyses, the groups classified by the dose rate (P = 0.010), total dose (P = 0.025), and conditioning regimen (P = 0.029) were significant factors for the development of PT. OS was significantly reduced when PT occurred (P < 0.001). However, the OS, relapse, and TRM were not different between the two groups.
conclusionsIn summary, about two-thirds of the patients undergoing daily TBI experienced PT, which affected OS. Therefore, reducing the dose rate (less than 6 cGy/min) of TBI can decrease the risk of PT, without compromising the treatment efficacy.
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