Evidence map›Paper›PMID 30227833›Full record

Trial reportBMC pregnancy and childbirth2018

Do elevated symptoms of depression predict adherence and outcomes in the UPBEAT randomised controlled trial of a lifestyle intervention for obese pregnant women?

Emma Molyneaux, Shahina Begum, Annette L Briley, Paul T Seed, Louise M Howard, Lucilla Poston, UPBEAT consortium

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Management of prepregnancy, pregnancy, and postpartum obesity from the FIGO Pregnancy and Non-Communicable Diseases Committee: A FIGO (International Federation of Gynecology and Obstetrics) guideline.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2020
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Emma MolyneauxSection of Women's Mental Health, Institute of Psychiatry, Psychology & Neuroscience at King's College London, London, England. emma.molyneaux@kcl.ac.uk.ORCID http://orcid.org/0000-0002-0696-5511
Shahina BegumDepartment of Women and Children's Health, King's College, London, England.
Annette L BrileyDepartment of Women and Children's Health, King's College, London, England.
Paul T SeedDepartment of Women and Children's Health, King's College, London, England.
Louise M HowardSection of Women's Mental Health, Institute of Psychiatry, Psychology & Neuroscience at King's College London, London, England.
Lucilla PostonDepartment of Women and Children's Health, King's College, London, England.
UPBEAT consortium
King's College London · GB

Funding

Chief Scientist Office Scottish Government Health Directorates CZB/A/680Department of Health NIHR-RP-R3-12-011Department of Health RP-PG-0407-10452Medical Research Council MR/M026361/1National Institute for Health Research NIHR-RP-R3-12-011National Institute for Health Research RP-PG-0407-10452
6 · The paper itself

Abstract

backgroundLifestyle interventions for obese pregnant women have been widely researched but little is known about predictors of low adherence or poor outcomes. This study evaluated the prospective associations between elevated symptoms of antenatal depression and gestational diabetes, adherence and gestational weight gain in a large RCT of a behavioural intervention for obese pregnant women. The effect of the intervention on symptoms of depression at follow-up was also examined.

methodsThe UPBEAT RCT randomised 1555 obese pregnant women to receive a dietary and physical activity lifestyle intervention or standard care. Symptoms of antenatal depression were assessed with the Edinburgh Postnatal Depression Scale at baseline (15

resultsOne thousand five-hundered twenty-six women were included in these analyses following multiple imputation; 797 (52.2%) had complete data. 13.4% had elevated symptoms of antenatal depression at baseline. There was no evidence for associations between antenatal depression status and gestational diabetes (adjusted OR 0.80, 95%CI 0.52 to 1.22, p = 0.30), adherence (adjusted OR 1.16, 95%CI 0.63 to 2.15, p = 0.63) or gestational weight gain (adjusted regression coefficient 0.52, 95%CI -0.26 to 1.29, p = 0.19). The intervention was not associated with change in depressive symptoms at follow-up (regression coefficient 0.003, 95%CI -0.49 to 0.49, p = 0.99). Similar results were obtained in complete case analyses.

conclusionsElevated symptoms of antenatal depression did not predict gestational diabetes, adherence or gestational weight gain in this large RCT of a lifestyle intervention for obese pregnant women. The intervention also did not influence symptoms of depression at follow-up. Obese pregnant women with elevated symptoms of depression should not be excluded from lifestyle interventions.

trial registrationISRCTN89971375 . Registered 28 November 2008.

Indexed as

Life StyleAdultBehavior TherapyDepressionDiabetes, GestationalFemaleHumansObesityPatient CompliancePregnancyPregnancy ComplicationsPrenatal CareWeight GainDepressionGestational diabetesGestational weight gainLifestyle interventionObesityPregnancy

Identifiers

PMID30227833
PMCPMC6142329
OpenAlexW2890494599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.