ArticleBMC infectious diseases2018
Virological failure among adolescents on ART, Harare City, 2017- a case-control study.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05278559 (Can Undetectable), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Undetectable (Viral Load) = Untransmissible (Virus) Change the Life Course of Adolescents Living the HIV in Africa
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Prevalence and factors associated with viral non-suppression in people living with HIV receiving antiretroviral therapy in sub-Saharan Africa: A systematic review and meta-analysis.Reviews in medical virology · 2024Pooled it
- Pooled it
- Alcohol Use, Risky Alcohol Use, and Associated Factors Among Adults Living with HIV in Urban Dar es Salaam, Tanzania.AIDS and behavior · 2026Trial
- Phase 2 Open-Label Study of Long-Term Safety, Tolerability, and Antiviral Activity of Rilpivirine in Antiretroviral-Naive Adolescents Living with HIV-1.Antimicrobial agents and chemotherapy · 2022Trial
- Cost-Effectiveness of Reducing HIV Infections Through Screening and Treating Alcohol Use and Depression in KwaZulu-Natal, South Africa: A Mathematical Modeling Study.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Underweight is associated with detectable viral load among adolescents with HIV in rural eastern Uganda: a retrospective cohort study.Journal of health, population, and nutrition · 2026Article
- Article
- Comparison of risky sexual behavior: Evidence from Zimbabwe Population-Based HIV Impact Assessment 2020.IJID regions · 2025Article
- Low HIV Viral Load Suppression and Its Implications for Controlling HIV among Refugee Adolescents and Youth Living in Refugee Settlements in Uganda: A Cross-sectional Analysis.AIDS and behavior · 2025Article
- Prevalence of detectable viral load and its associated factors among adult patients receiving ART in Choma District, Zambia.PloS one · 2025Article
- Factors Impacting Viral Load Suppression in Children and Adolescents Living with HIV Enrolled in an Orphans and Vulnerable Children Program in Northeast Nigeria.HIV/AIDS (Auckland, N.Z.) · 2025Article
- Bayesian meta-analysis of the effectiveness of implementation science evidence in improving health outcomes for adolescent patients accessing ART in sub-Saharan Africa.Frontiers in epidemiology · 2025Review
- HIV Virologic Suppression and Mental Well-being in Adolescents and Young Adults Living with HIV.International journal of MCH and AIDS · 2025Article
- Prevalence and Risk Factors of HIV Drug Resistance in Zimbabwe: Evidence from Zimbabwe Population-Based HIV Impact Assessment (ZIMPHIA) 2020 Survey.Tropical medicine and infectious disease · 2024Article
- Cost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study.BMC medicine · 2024Article
- Impact of enhanced adherence counselling on viral re-suppression among adolescents and young persons with persistent viremia.AIDS (London, England) · 2024Article
- Predictors for viral load suppression among HIV positive adults under ART treatment in University of Gondar Comprehensive Specialized Hospital: retrospective cohort study.Scientific reports · 2024Article
- Article
- Empowering adolescents living with perinatally-acquired HIV: tailored CD4+ count assessment for optimized care, the EDCTP READY-study.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundZimbabwe is on track towards achieving viral suppression among adults (87%). However, adolescents have only achieved 44% by 2016. In Harare city, 57% of adolescents had attained viral suppression after 12 months on ART compared to 88% among adults. We determined factors associated with virological failure among adolescents (age 10-19 years) on antiretroviral therapy (ART) in Harare city.
methodsWe conducted a one to one unmatched case control study among 102 randomly recruited case: control pairs at the two main infectious disease hospitals in Harare. A case was any adolescent who presented with VL > 1000c/ml after at least 12 months on ART. A control was any adolescent who presented with VL < 1000c/ml after at least 12 months on ART. Interviewer administered questionnaires were used to collect data. Epi Info 7 was used to generate frequencies, means, proportions, ORs and p-values at 95% CI.
resultsWe interviewed 102 case-control pairs. Poor adherence to ART [aOR = 8.15, 95% CI (2.80-11.70)], taking alcohol [aOR = 8.46, 95% CI (3.22-22.22)] and non- disclosure of HIV status [aOR = 4.56, 95% CI (2.20-9.46)] were independent risk factors for virological failure. Always using a condom [aOR = 0.04, 95% CI (0.01-0.35)], being on second line treatment [aOR = 0.04, 95% CI (0.23-0.81)] and belonging to a support group [aOR = 0.41, 95% CI (0.21-0.80)] were protective.
conclusionPoor adherence, alcohol consumption and non-disclosure increased the odds of virological failure. Based on these findings support should focus on behavior change and strengthening of peer to peer projects to help address issues related to disclosure and adherence. Further operational research should aim to define other components of effective adherence support for adolescents with virological failure.
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