Evidence map›Paper›PMID 30227612›Full record

ArticleDiseases (Basel, Switzerland)2018

Innovative Multi-Site Photoplethysmography Analysis for Quantifying Pulse Amplitude and Timing Variability Characteristics in Peripheral Arterial Disease.

Michael Bentham, Gerard Stansby, John Allen

Open access · goldAbstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  7. Review
  8. The 2023 wearable photoplethysmography roadmap.Physiological measurement · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Michael BenthamFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. m.bentham@ncl.ac.uk.
Gerard StansbyNorthern Vascular Centre, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK. gerard.stansby@nuth.nhs.uk.
John AllenNorthern Medical Physics and Clinical Engineering, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK. john.allen@nuth.nhs.uk.ORCID 0000-0002-7263-0533
Freeman Hospital · GBNewcastle University · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GB

Funding

Department of Health II-C1-0412-20003
6 · The paper itself

Abstract

Photoplethysmography (PPG) is a simple-to-perform vascular optics measurement technique that can detect blood volume changes in the microvascular bed of tissue. Beat-to-beat analysis of the PPG waveform enables the study of the variability of pulse features, such as the amplitude and the pulse arrival time (PAT), and when quantified in the time and frequency domains, has considerable potential to shed light on perfusion changes associated with peripheral arterial disease (PAD). In this pilot study, innovative multi-site bilateral finger and toe PPG recordings from 43 healthy control subjects and 31 PAD subjects were compared (recordings each at least five minutes, collected in a warm temperature-controlled room). Beat-to-beat normalized amplitude variability and PAT variability were then quantified in the time-domain using two simple statistical measures and in the frequency-domain bilaterally using magnitude squared coherence (MSC). Significantly reduced normalized amplitude variability (healthy control 0.0384 (interquartile range 0.0217⁻0.0744) vs. PAD 0.0160 (0.0080⁻0.0338) (

Indexed as

cardiovascular variabilityheart-rate variabilityperipheral arterial diseasephotoplethysmographypulse

Identifiers

PMID30227612
PMCPMC6165367
OpenAlexW2890834861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.