ReviewThe journal of pain2019
Contributions of Nociresponsive Area 3a to Normal and Abnormal Somatosensory Perception.
Review in The journal of pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Optogenetic Approach in Trigeminal Neuralgia and Potential Concerns: Preclinical Insights.Molecular neurobiology · 2024Review
- Arteriovenous malformation presenting as complex regional pain syndrome: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Neuropathic pain relief and altered brain networks after dorsal root entry zone microcoagulation in patients with spinal cord injury.Brain communications · 2024Article
- Cortical activity during the wind-up of flexion reflex and pain: a magnetoencephalographic study using time-frequency analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Effects and mechanisms of acupuncture analgesia mediated by afferent nerves in acupoint microenvironments.Frontiers in neuroscience · 2023Review
- Metabotropic Glutamate Receptor 5 in the Dysgranular Zone of Primary Somatosensory Cortex Mediates Neuropathic Pain in Rats.Biomedicines · 2022Article
- Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex.Nature communications · 2022Article
- Article
- Focality of the Induced E-Field Is a Contributing Factor in the Choice of TMS Parameters: Evidence from a 3D Computational Model of the Human Brain.Brain sciences · 2020Article
- Tactile force evokes a biphasic BOLD response in ipsilateral primary somatosensory cortex.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Traditionally, cytoarchitectonic area 3a of primary somatosensory cortex (SI) has been regarded as a proprioceptive relay to motor cortex. However, neuronal spike-train recordings and optical intrinsic signal imaging, obtained from nonhuman sensorimotor cortex, show that neuronal activity in some of the cortical columns in area 3a can be readily triggered by a C-nociceptor afferent drive. These findings indicate that area 3a is a critical link in cerebral cortical encoding of secondary/slow pain. Also, area 3a contributes to abnormal pain processing in the presence of activity-dependent reversal of gamma-aminobutyric acid A receptor-mediated inhibition. Accordingly, abnormal processing within area 3a may contribute mechanistically to generation of clinical pain conditions. PERSPECTIVE: Optical imaging and neurophysiological mapping of area 3a of SI has revealed substantial driving from unmyelinated cutaneous nociceptors, complementing input to areas 3b and 1 of SI from myelinated nociceptors and non-nociceptors. These and related findings force a reconsideration of mechanisms for SI processing of pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.