Evidence map›Paper›PMID 30227187›Full record

SynthesisProgress in cardiovascular diseases

Meta-analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-year Update.

Wesley J Tucker, Rhys I Beaudry, Yuanyuan Liang, Alexander M Clark, Corey R Tomczak, Michael D Nelson, Oyvind Ellingsen, Mark J Haykowsky

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 9 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 9 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Wesley J TuckerCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA.
Rhys I BeaudryCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA.
Yuanyuan LiangUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Alexander M ClarkFaculty of Nursing, University of Alberta, Edmonton, Alberta, Canada.
Corey R TomczakCollege of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Michael D NelsonCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA.
Oyvind EllingsenK. G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Department of Cardiology, St. Olav's Hospital, Trondheim, Norway.
Mark J HaykowskyCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA. Electronic address: mark.haykowsky@uta.edu.
The University of Texas at Arlington · USSt Olav's University Hospital · NOUniversity of Alberta · CAUniversity of Maryland, Baltimore · USUniversity of Saskatchewan · CA

Funding

Mechanisms and management of exercise intolerance in older heart failure patients with preserved ejection fraction (HFpEF)R15NR016826 · NINR · UNIVERSITY OF TEXAS ARLINGTON · PI HAYKOWSKY, MARK · 2017 to 2017
$308k
American Heart Association-American Stroke Association 18POST33990210NINR NIH HHS R15 NR016826
6 · The paper itself

Abstract

backgroundThe role of exercise training modality to attenuate left ventricular (LV) remodeling in heart failure patients with reduced ejection fraction (HFrEF) remains uncertain. The authors performed a systematic review and meta-analysis of published reports on exercise training (moderate-intensity continuous aerobic, high-intensity interval aerobic, and resistance exercise) and LV remodeling in clinically stable HFrEF patients.

methodsWe searched MEDLINE, Cochrane Central Registry of Controlled Trials, CINAHL, and PubMed (2007 to 2017) for randomized controlled trials of exercise training on resting LV ejection fraction (EF) and end-diastolic and end-systolic volumes in HFrEF patients.

results18 trials reported LV ejection fraction (LVEF) data, while 8 and 7 trials reported LV end-diastolic and LV end-systolic volumes, respectively. Overall, moderate-intensity continuous training (MICT) significantly increased LVEF (weighted mean difference, WMD = 3.79%; 95% confidence interval, CI, 2.08 to 5.50%) with no change in LV volumes versus control. In trials ≥6 months duration, MICT significantly improved LVEF (WMD = 6.26%; 95% CI 4.39 to 8.13%) while shorter duration (<6 months) trials modestly increased LVEF (WMD = 2.33%; 95% CI 0.84 to 3.82%). High-intensity interval training (HIIT) significantly increased LVEF compared to control (WMD = 3.70%; 95% CI 1.63 to 5.77%) but was not different than MICT (WMD = 3.17%; 95% CI -0.87 to 7.22%). Resistance training performed alone or combined with aerobic training (MICT or HIIT) did not significantly change LVEF.

conclusionsIn clinically stable HFrEF patients, MICT is an effective therapy to attenuate LV remodeling with the greatest benefits occurring with long-term (≥6 months) training. HIIT performed for 2 to 3 months is superior to control, but not MICT, for improvement of LVEF.

Indexed as

Exercise TherapyHeart FailureExerciseHumansStroke VolumeTreatment OutcomeVentricular Function, LeftVentricular RemodelingExercise therapyHigh-intensity interval trainingLeft ventricular ejection fractionModerate-intensity continuous trainingResistance training

Identifiers

PMID30227187
PMCPMC6445773
OpenAlexW2890388462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.