Evidence map›Paper›PMID 30226996›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2018

Insulin regulates GLUT4 in the ventromedial hypothalamus to restore the sympathoadrenal response to hypoglycemia in diabetic rats.

Rahul Agrawal, Adriana Vieira-de-Abreu, Griffin Durupt, Casey Taylor, Owen Chan, Simon J Fisher

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  2. Function of the GABAergic System in Diabetic Encephalopathy.Cellular and molecular neurobiology · 2023
    Review
  3. Insulin action in the brain regulates both central and peripheral functions.American journal of physiology. Endocrinology and metabolism · 2021
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rahul AgrawalDivision of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine , Salt Lake City, Utah.
Adriana Vieira-de-AbreuDivision of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine , Salt Lake City, Utah.
Griffin DuruptDivision of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine , Salt Lake City, Utah.
Casey TaylorDivision of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine , Salt Lake City, Utah.
Owen ChanDivision of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine , Salt Lake City, Utah.
Simon J FisherDivision of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine , Salt Lake City, Utah.
University of Utah · US

Funding

DIABETES ASSOCIATED BRAIN DAMAGE FOLLOWING SEVERE HYPOGLYCEMIAR01NS070235 · NINDS · WASHINGTON UNIVERSITY · PI FISHER, SIMON J · 2010 to 2014
$1.5M
NINDS NIH HHS R01 NS070235
6 · The paper itself

Abstract

It is proposed that the impaired counterregulatory response (CRR) to hypoglycemia in insulin-deficient diabetes may be due to chronic brain insulin deficiency. To test this hypothesis, streptozotocin-induced diabetic Sprague-Dawley rats were infused with insulin (3 mU/day) or artificial cerebrospinal fluid (aCSF) bilaterally into the ventromedial hypothalamus (VMH) for 2 wk and compared with nondiabetic rats. Rats underwent hyperinsulinemic (50 mU·kg

Indexed as

AnimalsBlood GlucoseDiabetes Mellitus, ExperimentalEpinephrineGlucagonGlucose Clamp TechniqueGlucose Transporter Type 4HypoglycemiaHypoglycemic AgentsInsulinMaleRatsRats, Sprague-DawleyVentromedial Hypothalamic NucleusBlood GlucoseEpinephrineGlucagonGlucose Transporter Type 4Hypoglycemic AgentsInsulinGLUT4hypoglycemiainsulinventromedial hypothalamus

Identifiers

PMID30226996
PMCPMC6336954
OpenAlexW2891378537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.