ArticlePLoS neglected tropical diseases2018
Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- New area of occurrence of human brucellosis in Brazil: serological and molecular prevalence and risk factors associated with Brucella abortus infection.One health outlook · 2025Article
- Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat.Irish veterinary journal · 2025Article
- A first insight into seropositivity and risk factors forOne health (Amsterdam, Netherlands) · 2024Article
- Case Report: Acute Brucellosis Due to Brucella suis in a Brazilian Gold Miner Diagnosed in French Guiana.The American journal of tropical medicine and hygiene · 2023Article
- Management of bovine brucellosis in organized dairy herds through the identification of risk factors: A cross-sectional study from Karnataka, India.Veterinary world · 2023Article
- Brucellosis in the Brazilian Pantanal wetland: threat to animal production and wildlife conservation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Diagnostic and therapeutic approach to chronic meningitis in Brazil: a narrative review.Arquivos de neuro-psiquiatria · 2022Review
- Spatiotemporal Pattern Evolution and Driving Factors of Brucellosis in China, 2003-2019.International journal of environmental research and public health · 2022Article
- Dairy Cattle Euthanasia-Focus Groups Exploring the Perspectives of Brazilians Working in the Dairy Cattle Industry.Animals : an open access journal from MDPI · 2022Article
- Epidemiological characterization of notified human brucellosis cases in Southern Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Importance of brucellosis control programs of livestock on the improvement of one health.The veterinary quarterly · 2021Review
- Article
- The seroprevalence of brucellosis and molecular characterization of Brucella species circulating in the beef cattle herds in Albania.PloS one · 2020Article
- Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman brucellosis (HB) is a bacterial zoonosis that is more frequent in low income and middle-income countries; it is sometimes associated with outbreaks. The aim of this study was to describe the largest outbreak of HB in Brazil.
methodsA retrospective cohort study of patients suspected of having contracted HB in the state of Paraná, Southern Brazil from January 2009 to January 2017. Following an outbreak of 51 cases of HB in a slaughterhouse at Paiçandu in 2014, HB was defined as an obligatory reportable disease in the State. Diagnostic tests for HB included serum agglutination, ELISA (IgG or IgM) and polymerase chain reaction (PCR). Clinical, laboratorial and epidemiological data were analyzed. A P value of 0.05 was considered statistically significant.
resultsOut of a total of 3,941 patients, 754 presented with a positive test result for HB. After 2014, there was a significant increase in the number of cases, exceeding 100 cases per trimester. In the beginning of 2015, the workgroup of HB started several actions for prevention and treatment, and the number of cases progressively diminished to fewer than 20 cases per trimester. Of 191 reported cases, an occupational risk was found in 84.7%; most cases occurred in farmers (60.0%), veterinarians (17.6%) and slaughterhouse workers (14.7%). Manipulation of animals and unpasteurized milk consumption were associated with positive Brucella IgM ELISA with an odds ratio (OR) of 1.42 (1.09-1.84) and 1.48 (1.01-2.15), respectively.
conclusionsHB outbreaks can occur in low to middle-income countries and are associated with slaughterhouse work, handling of unpasteurized milk and animal manipulation. Intensive programs for control of HB are important to reduce the number of cases.
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