ArticlePLoS genetics2018
Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Color patterns as a model for connecting developmental mechanisms to phenotypic evolution.Nature communications · 2026Review
- Zebrafish relatives as models for functional comparative genetics and genomics.Nature reviews. Genetics · 2026Review
- DNA methylation of the endothelin receptor B makes blue fish yellow.Nature communications · 2025Article
- Genomic and genetic insights into speciation and pigment pattern diversification inbioRxiv : the preprint server for biology · 2025Article
- The genome sequences ofWellcome open research · 2025Article
- Review
- An allelic series at the EDNRB2 locus controls diverse piebalding patterns in the domestic pigeon.PLoS genetics · 2023Article
- Article
- kcnj13 regulates pigment cell shapes in zebrafish and has diverged by cis-regulatory evolution between Danio species.Development (Cambridge, England) · 2023Article
- Stripes and loss of color in ball pythons (Python regius) are associated with variants affecting endothelin signaling.G3 (Bethesda, Md.) · 2023Article
- Plate-like Guanine Biocrystals Form via Templated Nucleation of Crystal Leaflets on Preassembled Scaffolds.Journal of the American Chemical Society · 2022Article
- A highly contiguous nuclear genome assembly of the mandarinfish Synchiropus splendidus (Syngnathiformes: Callionymidae).G3 (Bethesda, Md.) · 2021Article
- Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects.Biology open · 2021Article
- Article
- Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes.Developmental biology · 2021Article
- Evolution of pigment cells and patterns: recent insights from teleost fishes.Current opinion in genetics & development · 2021Review
- The application of genome editing technology in fish.Marine life science & technology · 2021Review
- Transcriptomic Analysis of Skin Color in Anole Lizards.Genome biology and evolution · 2021Article
- Thyroid hormones regulate the formation and environmental plasticity of white bars in clownfishes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots.PLoS genetics · 2021Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Fishes of the genus Danio exhibit diverse pigment patterns that serve as useful models for understanding the genes and cell behaviors underlying the evolution of adult form. Among these species, zebrafish D. rerio exhibit several dark stripes of melanophores with sparse iridophores that alternate with light interstripes of dense iridophores and xanthophores. By contrast, the closely related species D. nigrofasciatus has an attenuated pattern with fewer melanophores, stripes and interstripes. Here we demonstrate species differences in iridophore development that presage the fully formed patterns. Using genetic and transgenic approaches we identify the secreted peptide Endothelin-3 (Edn3)-a known melanogenic factor of tetrapods-as contributing to reduced iridophore proliferation and fewer stripes and interstripes in D. nigrofasciatus. We further show the locus encoding this factor is expressed at lower levels in D. nigrofasciatus owing to cis-regulatory differences between species. Finally, we show that functions of two paralogous loci encoding Edn3 have been partitioned between skin and non-skin iridophores. Our findings reveal genetic and cellular mechanisms contributing to pattern differences between these species and suggest a model for evolutionary changes in Edn3 requirements for pigment patterning and its diversification across vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.