Evidence map›Paper›PMID 30226811›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Kinetics of corneal leukocytes by intravital multiphoton microscopy.

Yashar Seyed-Razavi, Maria J Lopez, Dimosthenis Mantopoulos, Lixin Zheng, Steffen Massberg, Victor G Sendra, Deshea L Harris, Pedram Hamrah

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Plasmacytoid dendritic cells in the eye.Progress in retinal and eye research · 2021
    Review
  11. In vivo immune cell dynamics in the human cornea.Experimental eye research · 2020
    Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yashar Seyed-RazaviCenter for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, Boston, Massachusetts, USA.
Maria J LopezCenter for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, Boston, Massachusetts, USA.
Dimosthenis MantopoulosSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
Lixin ZhengSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
Steffen MassbergDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Victor G SendraCenter for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, Boston, Massachusetts, USA.
Deshea L HarrisCenter for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, Boston, Massachusetts, USA.
Pedram HamrahCenter for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, Boston, Massachusetts, USA.
Harvard University · USMassachusetts Eye and Ear Infirmary · USTufts Medical Center · USLudwig-Maximilians-Universität München · DE

Funding

Mass Eye and Ear-Vision Clinical Scientist Development ProgramK12EY016335 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Reza Dana · 2004 to 2026
$12.3M
Mechanisms of Corneal Neuro-Immune CrosstalkR01EY029602 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI Pedram Hamrah · 2018 to 2026
$3.6M
The role of plasmacytoid dendritic cells in corneal immunityR01EY022695 · NEI · TUFTS MEDICAL CENTER · PI HAMRAH, PEDRAM · 2013 to 2017
$2.4M
Immunobiology of Corneal Antigen-Presenting CellsK08EY020575 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI HAMRAH, PEDRAM · 2010 to 2013
$914k
NEI NIH HHS K08 EY020575NEI NIH HHS K12 EY016335NEI NIH HHS R01 EY022695NEI NIH HHS R01 EY029602
6 · The paper itself

Abstract

Corneal immune privilege is integral in maintaining the clear avascular window to the foreign world. The presence of distinct populations of corneal leukocytes (CLs) in the normal cornea has been firmly established. However, their precise function and kinetics remain, as of yet, unclear. Through intravital multiphoton microscopy (IV-MPM), allowing the means to accumulate critical spatial and temporal cellular information, we provide details for long-term investigation of CL morphology and kinetics under steady state and following inflammation. Significant alterations in size and morphology of corneal CD11c

Indexed as

AnimalsCorneaLeukocytesMice, Inbred C57BLMice, TransgenicMicroscopyPhotonsantigen-presenting cellscell morphologydendritic cellskeratitisMHC-II

Identifiers

PMID30226811
PMCPMC6338630
OpenAlexW2891114432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.