Evidence map›Paper›PMID 30226442›Full record

ArticleTissue engineering. Part A2019

The Effects of Metabolic Substrate Availability on Human Adipose-Derived Stem Cell Spheroid Survival.

Robert Coyle, Jenny Yao, Dylan Richards, Ying Mei

Abstract read
In one paragraph

Article in Tissue engineering. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Targeting HIF-α for robust prevascularization of human cardiac organoids.Journal of tissue engineering and regenerative medicine · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert Coyle1 Department of Bioengineering, Clemson University , Charleston, South Carolina.
Jenny Yao2 Academic Magnet High School , North Charleston, South Carolina.
Dylan Richards1 Department of Bioengineering, Clemson University , Charleston, South Carolina.
Ying Mei1 Department of Bioengineering, Clemson University , Charleston, South Carolina.

Funding

Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R, VYAVAHARE, NAREN R · 2012 to 2018
$14.9M
TRAINING TO IMPROVE CARDIOVASCULAR THERAPIEST32HL007260 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MENICK, DONALD R. · 1985 to 2021
$11.1M
SC COBRE for Developmentally Based Cardiovascular DiseasesP30GM103342 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MARKWALD, ROGER R · 2012 to 2016
$5.5M
Nanowired human cardiac spheroids for heart repairR01HL133308 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL133308NHLBI NIH HHS T32 HL007260NIGMS NIH HHS P20 GM103444NIGMS NIH HHS P30 GM103342
6 · The paper itself

Abstract

impact statementHuman adipose-derived stem cells (hADSCs) spheroids have displayed remarkable potential for treating ischemic injury. However, low nutrient (i.e., glucose and oxygen) availability in ischemic environments results in limited tissue viability posttransplantation. To develop an understanding of the effects of nutrient availability on spheroid survival, we utilized both

Indexed as

Adipose TissueCell DifferentiationCells, CulturedHumansIschemiaModels, TheoreticalSpheroids, CellularStem Cells3D tissue cultureadipose-derived stem cellischemiamathematical modelingnutrient diffusionspheroid

Identifiers

PMID30226442
PMCPMC6482921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.