Evidence map›Paper›PMID 30226401›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Phosphorus spectroscopy in acute TBI demonstrates metabolic changes that relate to outcome in the presence of normal structural MRI.

Matthew G Stovell, Marius O Mada, T Adrian Carpenter, Jiun-Lin Yan, Mathew R Guilfoyle, Ibrahim Jalloh, Karen E Welsh, Adel Helmy, Duncan J Howe, Peter Grice and 7 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Patient-Centered Approaches to Cognitive Assessment in Acute TBI.Current neurology and neuroscience reports · 2023
    Review
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Matthew G StovellDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4172-4617
Marius O MadaWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
T Adrian CarpenterWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Jiun-Lin YanDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Mathew R GuilfoyleDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Ibrahim JallohDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Karen E WelshWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Adel HelmyDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Duncan J HoweDepartment of Chemistry, University of Cambridge, Cambridge, UK.
Peter GriceDepartment of Chemistry, University of Cambridge, Cambridge, UK.
Andrew MasonDepartment of Chemistry, University of Cambridge, Cambridge, UK.
Susan Giorgi-CollDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Clare N GallagherDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Michael P MurphyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
David K MenonWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Peter J HutchinsonDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Keri Lh CarpenterDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
University of Cambridge · GBChang Gung University · TWUniversity of Calgary · CA

Funding

CIHRDepartment of Health HTA/13/15/02Department of Health NIHR-RP-R3-12-013Medical Research Council G0600986Medical Research Council G0802251Medical Research Council G1002277Medical Research Council MC_PC_17156Medical Research Council MC_U105663142Medical Research Council MC_UU_00015/3Medical Research Council MR/N025792/1Wellcome Trust 110158/Z/15/ZWellcome Trust 110159/Z/15/Z
6 · The paper itself

Abstract

Metabolic dysfunction is a key pathophysiological process in the acute phase of traumatic brain injury (TBI). Although changes in brain glucose metabolism and extracellular lactate/pyruvate ratio are well known, it was hitherto unknown whether these translate to downstream changes in ATP metabolism and intracellular pH. We have performed the first clinical voxel-based

Indexed as

PhosphorusAdenosine TriphosphateAdultAlkalosisBrain Injuries, TraumaticCase-Control StudiesEnergy MetabolismFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrognosisAdenosine TriphosphatePhosphorus31P magnetic resonance spectroscopyadenosine triphosphateclinical outcomepHtraumatic brain injury (human)

Identifiers

PMID30226401
PMCPMC6927074
OpenAlexW2891325199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.