ArticleEmerging infectious diseases2018
Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 93 citations in OpenAlex.
- Identification and characterization of non-canonical azole antifungal resistance pathways inmBio · 2026Article
- A long noncoding RNA regulates in vitro and in vivo triazole antifungal susceptibility in Aspergillus fumigatus.Genetics · 2026Article
- Antifungal resistance: from classical mechanisms to the expanding role of acetyltransferases.Journal of biomedical science · 2026Review
- Human natural killer cells exhibit potent antifungal activity against azole-resistantMicrobiology spectrum · 2026Article
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- Molecular and Phenotypic Characterization of Multidrug-ResistantJournal of fungi (Basel, Switzerland) · 2026Article
- Azole Resistance inOpen forum infectious diseases · 2026Article
- Global epidemiology of azole resistance inJAC-antimicrobial resistance · 2026Review
- Understanding multi-azole resistance inFrontiers in fungal biology · 2026Article
- Sexual reproduction and the polygenic architecture of azole resistance in agricultural populations ofFrontiers in microbiology · 2026Article
- Current Evidence on Voriconazole Exposure and Individualized Therapy for Aspergillosis.Infection and drug resistance · 2026Review
- Triazole Resistance and Misidentification of Aspergillus tubingensis in Southern California.JAMA network open · 2025Article
- A long non-coding RNA regulates triazole antifungal susceptibility and virulence inbioRxiv : the preprint server for biology · 2025Article
- Azole-ResistantJournal of fungi (Basel, Switzerland) · 2025Review
- RttA, a ZnMicrobiology spectrum · 2025Article
- Comparative genomics and transcriptomics identifyiScience · 2025Article
- Article
- Epidemiology, antifungal susceptibility and biological characteristics of clinical Aspergillus fumigatus in a tertiary hospital.Scientific reports · 2025Article
- Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Review
13 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent increase in azole-resistant Aspergillus fumigatus is a global concern. Identifying the mutations that confer azole resistance is essential for developing novel methods for prompt diagnosis and effective drug treatment. We screened A. fumigatus clinical isolates for novel mutations conferring azole resistance. We compared the genomic sequences of susceptible and resistant isolates without mutations in cyp51A (non-cyp51A) and found mutations in hmg1 and erg6 involved in ergosterol biosynthesis. We also found the novel mutations in these genes in azole-resistant isolates with different genetic backgrounds. The resistant isolates with mutations in hmg1 showed increased intracellular ergosterol levels compared with susceptible isolates. This finding supports the concept that the ergosterol level is a determinant for resistance to any class of azoles. Multiple isolates with increased resistance to azole possessed a mutation in hmg1, indicating that this mutation is widely present in non-cyp51A azole-resistant A. fumigatus.
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